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Volume 2011 (2011), Article ID 765624, 8 pages
The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis
Product Research Department, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan
Received 21 December 2010; Revised 15 February 2011; Accepted 22 March 2011
Academic Editor: Burkhard Leeb
Copyright © 2011 Misato Hashizume and Masahiko Mihara. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [37 citations]
The following is the list of published articles that have cited the current article.
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- Dong-Gun Lee, Jung-Won Woo, Seung-Ki Kwok, Mi-La Cho, and Sung-Hwan Park, “MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis,” Experimental & Molecular Medicine, vol. 45, no. 4, pp. e20, 2013.
- Jian Jin, Liang Wang, Xiao-kai Wang, Ping-lin Lai, Min-jun Huang, Da-di Jin, Zhao-ming Zhong, Jian-ting Chen, and Xiao-chun Bai, “Risedronate inhibits bone marrow mesenchymal stem cell adipogenesis and switches RANKL/OPG ratio to impair osteoclast differentiation,” Journal of Surgical Research, vol. 180, no. 1, pp. e21–e29, 2013.
- Md Yuzaiful Md Yusof, and Paul Emery, “Targeting Interleukin-6 in Rheumatoid Arthritis,” Drugs, vol. 73, no. 4, pp. 341–356, 2013.
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- T Nagasaki, M Hara, H Nakanishi, H Takahashi, M Sato, and H Takeyama, “Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction,” British Journal of Cancer, 2013.
- Shoichi Kaneshiro, Kosuke Ebina, Kenrin Shi, Chikahisa Higuchi, Makoto Hirao, Michio Okamoto, Kota Koizumi, Tokimitsu Morimoto, Hideki Yoshikawa, and Jun Hashimoto, “IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro,” Journal of Bone and Mineral Metabolism, 2013.
- Patrick H. Dessein, Ahmed Solomon, Angela J. Woodiwiss, Gavin R. Norton, Linda Tsang, and Miguel A. Gonzalez-Gay, “Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis,” Mediators of Inflammation, vol. 2013, pp. 1–10, 2013.
- Addolorata Corrado, Anna Neve, Nicola Maruotti, and Francesco Paolo Cantatore, “Bone Effects of Biologic Drugs in Rheumatoid Arthritis,” Clinical and Developmental Immunology, vol. 2013, pp. 1–7, 2013.
- Ziv Rosman, Yehuda Shoenfeld, and Gisele Zandman-Goddard, “Biologic therapy for autoimmune diseases: an update,” BMC Medicine, vol. 11, no. 1, pp. 88, 2013.
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- Israa Al-Shakarchi, Nicola J. Gullick, and David L. Scott, “Current perspectives on tocilizumab for the treatment of rheumatoid arthritis: a review,” Patient Preference And Adherence, vol. 7, pp. 653–666, 2013.
- Ryuichi Kunii, Masaru Yamaguchi, Yasuhiro Tanimoto, Masaki Asano, Kunihiko Yamada, Takemi Goseki, and Kazutaka Kasai, “Role of interleukin-6 in orthodontically induced inflammatory root resorption in humans,” The Korean Journal of Orthodontics, vol. 43, no. 6, pp. 294, 2013.
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- Jeffrey R. Curtis, Susana Perez-Gutthann, Samy Suissa, Pavel Napalkov, Natasha Singh, Liz Thompson, and Benjamin Porter-Brown, “Tocilizumab in rheumatoid arthritis: A case study of safety evaluations of a large postmarketing data set from multiple data sources,” Seminars in Arthritis and Rheumatism, 2014.
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- Guo Tian, Jiao-Long Li, De-Guang Wang, and Dian Zhou, “Targeting IL-10 in Auto-immune Diseases,” Cell Biochemistry and Biophysics, 2014.
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- Alejandro Souto, Eva Salgado, José Ramón Maneiro, Antonio Mera, Loreto Carmona, and Juan J. Gómez-Reino, “Lipid Profile Changes in Patients With Chronic Inflammatory Arthritis Treated With Biologic Agents and Tofacitinib in Randomized Clinical Trials: A Systematic Review and Meta-Analysis,” Arthritis & Rheumatology, vol. 67, no. 1, pp. 117–127, 2014.
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- Torsten Witte, “Methotrexate as combination partner of TNF inhibitors and tocilizumab. What is reasonable from an immunological viewpoint?,” Clinical Rheumatology, 2015.
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