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Volume 2011 (2011), Article ID 765624, 8 pages
The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis
Product Research Department, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan
Received 21 December 2010; Revised 15 February 2011; Accepted 22 March 2011
Academic Editor: Burkhard Leeb
Copyright © 2011 Misato Hashizume and Masahiko Mihara. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [38 citations]
The following is the list of published articles that have cited the current article.
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- N. Narkbunnam, J. Sun, G. Hu, F.-C. Lin, T. A. Bateman, M. Mihara, and P. E. Monahan, “IL-6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding-induced arthropathy in hemophilia,” Journal of Thrombosis and Haemostasis, vol. 11, no. 5, pp. 881–893, 2013.
- Dong-Gun Lee, Jung-Won Woo, Seung-Ki Kwok, Mi-La Cho, and Sung-Hwan Park, “MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis,” Experimental & Molecular Medicine, vol. 45, no. 4, pp. e20, 2013.
- Md Yuzaiful Md Yusof, and Paul Emery, “Targeting Interleukin-6 in Rheumatoid Arthritis,” Drugs, vol. 73, no. 4, pp. 341–356, 2013.
- Jian Jin, Liang Wang, Xiao-kai Wang, Ping-lin Lai, Min-jun Huang, Da-di Jin, Zhao-ming Zhong, Jian-ting Chen, and Xiao-chun Bai, “Risedronate inhibits bone marrow mesenchymal stem cell adipogenesis and switches RANKL/OPG ratio to impair osteoclast differentiation,” Journal of Surgical Research, vol. 180, no. 1, pp. e21–e29, 2013.
- Zhi-feng Wei, Xiao-lan Jiao, Ting Wang, Qian Lu, Yu-feng Xia, Zheng-tao Wang, Qing-long Guo, Gui-xin Chou, and Yue Dai, “Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL, IL-6, PGE2, and MMP-13 expression,” Acta Pharmacologica Sinica, vol. 34, no. 3, pp. 403–413, 2013.
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- Christoph Boehler, Helga Radner, Josef S. Smolen, and Daniel Aletaha, “Serological changes in the course of traditional and biological disease modifying therapy of rheumatoid arthritis,” Annals Of The Rheumatic Diseases, vol. 72, no. 2, pp. 241–244, 2013.
- T Nagasaki, M Hara, H Nakanishi, H Takahashi, M Sato, and H Takeyama, “Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction,” British Journal of Cancer, 2013.
- Shoichi Kaneshiro, Kosuke Ebina, Kenrin Shi, Chikahisa Higuchi, Makoto Hirao, Michio Okamoto, Kota Koizumi, Tokimitsu Morimoto, Hideki Yoshikawa, and Jun Hashimoto, “IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro,” Journal of Bone and Mineral Metabolism, 2013.
- Patrick H. Dessein, Ahmed Solomon, Angela J. Woodiwiss, Gavin R. Norton, Linda Tsang, and Miguel A. Gonzalez-Gay, “Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis,” Mediators of Inflammation, vol. 2013, pp. 1–10, 2013.
- Addolorata Corrado, Anna Neve, Nicola Maruotti, and Francesco Paolo Cantatore, “Bone Effects of Biologic Drugs in Rheumatoid Arthritis,” Clinical and Developmental Immunology, vol. 2013, pp. 1–7, 2013.
- Ziv Rosman, Yehuda Shoenfeld, and Gisele Zandman-Goddard, “Biologic therapy for autoimmune diseases: an update,” BMC Medicine, vol. 11, no. 1, pp. 88, 2013.
- Ryuichi Kunii, Masaru Yamaguchi, Yasuhiro Tanimoto, Masaki Asano, Kunihiko Yamada, Takemi Goseki, and Kazutaka Kasai, “Role of interleukin-6 in orthodontically induced inflammatory root resorption in humans,” The Korean Journal of Orthodontics, vol. 43, no. 6, pp. 294, 2013.
- Yi-fan Dai, Tian-yu Chen, Xiao-chun Bai, Xiao-chen Zheng, Ping-lin Lai, Jia Liu, Liang Wang, Jian Chen, Da-di Jin, Zhong-min Zhang, Min-jun Huang, Si Qin, and Cheng-liang Yang, “Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice,” Drug Design Development And Therapy, vol. 7, pp. 545–552, 2013.
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- Misato Hashizume, Seng-Lai Tan, Junichi Takano, Kazunori Ohsawa, Ikuo Hasada, Akira Hanasaki, Ichiro Ito, Masahiko Mihara, and Keiichiro Nishida, “Tocilizumab, A Humanized Anti-IL-6R Antibody, as an Emerging Therapeutic Option for Rheumatoid Arthritis: Molecular and Cellular Mechanistic Insights,” International Reviews of Immunology, pp. 140806053603007, 2014.
- Jeffrey R. Curtis, Susana Perez-Gutthann, Samy Suissa, Pavel Napalkov, Natasha Singh, Liz Thompson, and Benjamin Porter-Brown, “Tocilizumab in rheumatoid arthritis: A case study of safety evaluations of a large postmarketing data set from multiple data sources,” Seminars in Arthritis and Rheumatism, 2014.
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- Ping-Wei Zhao, Wei-Guang Jiang, Li Wang, Zhen-Yu Jiang, Yu-Xing Shan, and Yan-Fang Jiang, “Plasma Levels of IL-37 and Correlation with TNF-alpha, IL-17A, and Disease Activity during DMARD Treatment of Rheumatoid Arthritis,” Plos One, vol. 9, no. 5, 2014.
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- Guo Tian, Jiao-Long Li, De-Guang Wang, and Dian Zhou, “Targeting IL-10 in Auto-immune Diseases,” Cell Biochemistry and Biophysics, 2014.
- Samir M. Abdelmagid, Mary F. Barbe, and Fayez F. Safadi, “Role of inflammation in the aging bone,” Life Sciences, 2014.
- Alejandro Souto, Eva Salgado, José Ramón Maneiro, Antonio Mera, Loreto Carmona, and Juan J. Gómez-Reino, “Lipid Profile Changes in Patients With Chronic Inflammatory Arthritis Treated With Biologic Agents and Tofacitinib in Randomized Clinical Trials: A Systematic Review and Meta-Analysis,” Arthritis & Rheumatology, vol. 67, no. 1, pp. 117–127, 2014.
- Chunyan He, Xiaohui Chen, Chunyang Zhao, Yanyan Qie, Zhaowei Yan, and Xueming Zhu, “Eleutheroside E Ameliorates Arthritis Severity in Collagen-Induced Arthritis Mice Model by Suppressing Inflammatory Cytokine Release,” Inflammation, vol. 37, no. 5, pp. 1533–1543, 2014.
- Yao Liu, Jun Lv, Bo Yang, Fang Liu, Zhiqiang Tian, Yongqing Cai, Di Yang, Jing Ouyang, Fengjun Sun, Ying Shi, and Peiyuan Xia, “Lycium barbarum polysaccharide attenuates type II collagen-induced arthritis in mice,” International Journal of Biological Macromolecules, 2015.
- Torsten Witte, “Methotrexate as combination partner of TNF inhibitors and tocilizumab. What is reasonable from an immunological viewpoint?,” Clinical Rheumatology, 2015.
- Ulrich Grosse, Jörg Henes, Gerd Grözinger, Ina Kötter, Petros Martirosian, Frank Eibofner, Fritz Schick, and Marius Horger, “Anatomic-Functional (Perfusion-Based) Magnetic Resonance Imaging Follow-up in Patients With Rheumatoid Arthritis Treated With Anti–Interleukin 6 Antibodies,” Journal of Computer Assisted Tomography, vol. 39, no. 1, pp. 75–82, 2015.