Figure 4: Serum lipid levels in IL-6-treated mice . (a) Experimental protocol. Mice () were given i.p. IL-6 (20 μg) or phosphate buffered saline (PBS) twice a day 5 days per week for 2 weeks. (b) Serum total cholesterol and triglyceride levels were measured with an automatic analyzer. Closed and open circles indicate control and IL-6-treated mice, respectively. The horizontal bar indicates mean of values. Statistical significance between the control and the IL-6 group on days 0, 7, and 14 was analyzed by unpaired -test (***).