Table 1: IL-17 in murine models of lupus.

ModelDescriptionReferences

BXD2IL-17 promotes spontaneous GC development as well as autoantibody production by IL-17R+ B cells[82, 83]
MRL.lpr Expansion of IL-17-producing DNT cells with kidney infiltration and GN induction[91, 92]
SNF1Enhanced IL-17 production by CD4+ T cells with kidney infiltration[94]
NZM2328Disruption of TNFα promotes Th17 development[97]