Table 2: Frequency of the used outcomes listed according to their frequency in the included trials.

Pain outcome (scale)Number of trials
(%)
Number of substudies
(%)
Mean rank in responsiveness (range)

WOMAC pain (Likert scale)15 (43%)20 (37%)1.8 (1–4)
Global knee pain (VAS)13 (37%)17 (31%)1.7 (1–4)
WOMAC pain (100 mm scale)12 (34%)21 (39%)1.9 (1–4)
Pain during activity (VAS)12 (34%)18 (33%)1.4 (1–5)
Pain during walking (VAS)7 (20%)12 (22%)1.5 (1–3)
Pain at rest (VAS)7 (20%)12 (22%)2.3 (1–4)
SF-36 (bodily pain (BP) subscale)6 (17%)8 (15%)2.3 (1–4)
Pain at night (VAS)2 (6%)4 (7%)3.0 (3)
HAQ (pain subscale)1 (3%)4 (7%)1.5 (1-2)
Lequesne algofunctional index (pain subscale)1 (3%)2 (4%)1.5 (1-2)
Pain during activity (NRS)1 (3%)2 (4%)2.5 (1–4)
Pain during walking (NRS)1 (3%)2 (4%)2.5 (2-3)
Number of painful days (days)1 (3%)2 (4%)1.0 (1)
AIMS (pain subscale)1 (3%)2 (4%)1.5 (1-2)
Knee-Specific Pain Scale (KSPS)1 (3%)2 (4%)2.5 (2-3)
McGill Pain Questionnaire (pain intensity)1 (3%)1 (2%)2.0 (2)
ASES (pain subscale)1 (3%)1 (2%)2.0 (2)
SES (Schmerzempfindungsskala)1 (3%)1 (2%)2.0 (2)

Disability outcome (scale)Number of trials
(%)
Number of substudies
(%)
Mean rank in responsiveness (range)

Physical composite score (PFC) (based on SF-36, SF-12, or SF-8)9 (60%)11 (52%)1.8 (1–3)
WOMAC function (100 mm scale)8 (53%)13 (62%)1.5 (1-2)
WOMAC function (Likert scale)7 (47%)8 (38%)1.5 (1-2)
SF-36 (physical function PF subscale)7 (47%)8 (38%)1.8 (1-2)
HAQ (disability subscale)1 (7%)4 (19%)1.5 (1-2)
PDI (pain disability index)1 (7%)1 (5%)2.0 (2)
ASES (disability subscale)1 (7%)1 (5%)2.0 (2)

WOMAC (Western Ontario and McMaster Universities Arthritis Index), VAS (visual analogue scale), NRS (Numerical Rating Scale), AIMS (Arthritis Impact Measurement Scale), ASES (Arthritis Self Efficacy Scale), HAQ (Health Assessment Questionnaire), PDI (Pain Disability Index), SES (Schmerzempfindungsskala) (Pain Experience Scale), SF-36 (Short Form 36), SF-12 (Short Form 12), SF-8 (Short Form 8).