Table 1: Major susceptibility genes associated with primary biliary cirrhosis (PBC), as reported through genome-wide association studies. Note that several positive associations are shared between PBC and rheumatoid arthritis (RA).

GenePBC RA

HLA
 DR8+
 DQB1++
 DRB1+
 DQA1+
 DQA2+
Non-HLA
 STAT4++
 SPIB+
 IRF5++
 IL12A+
 IL12RB+
 MMEL1++
 CXCR5+ ?
 NFKB1+
 CTLA4++

?: question mark indicates that there are no conclusive data regarding the role of CCXR5 as a risk factor in RA, with some reports providing data in support and other against.