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Arthritis
Volume 2012 (2012), Article ID 741582, 8 pages
http://dx.doi.org/10.1155/2012/741582
Review Article

Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic Approaches

1Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
2Department of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USA
3Department of Orthopaedic Surgery, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA

Received 12 January 2012; Revised 4 April 2012; Accepted 26 April 2012

Academic Editor: Changhai Ding

Copyright © 2012 Roshni Rainbow et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It is increasingly recognized that the pathogenesis of cartilage degradation in osteoarthritis (OA) is multifactorial and involves the interactions between cartilage and its surrounding tissues. These interactions regulate proinflammatory cytokine-mediated cartilage destruction, contributing to OA progression as well as cartilage repair. This review explores the pathogenesis of OA in the context of the multiple tissue types in the joint and discusses the implications of such complex tissue interaction in the development of anti-inflammatory therapeutics for the treatment of OA.