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Arthritis
Volume 2012 (2012), Article ID 943156, 7 pages
http://dx.doi.org/10.1155/2012/943156
Research Article

Proinflammatory Soluble Interleukin-15 Receptor Alpha Is Increased in Rheumatoid Arthritis

1Pharmaceutical Division, Center for Genetic Engineering and Biotechnology, 10600 Havana, Cuba
2Rheumatology Department, H. Ameijeiras Hospital, San Lazaro 701, 10300 Havana, Cuba

Received 20 February 2012; Revised 17 April 2012; Accepted 25 May 2012

Academic Editor: Adriana Rojas-Villarraga

Copyright © 2012 Ana Cecilia Machado Diaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. B. McInnes and G. Schett, “Cytokines in the pathogenesis of rheumatoid arthritis,” Nature Reviews Immunology, vol. 7, no. 6, pp. 429–442, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. I. B. Mcinnes, J. Al-Mughales, M. Field et al., “The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis,” Nature Medicine, vol. 2, no. 2, pp. 175–182, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. H. P. Carroll, V. Paunović, and M. Gadina, “Signalling, inflammation and arthritis: crossed signals: the role of interleukin-15 and -18 in autoimmunity,” Rheumatology, vol. 47, no. 9, pp. 1269–1277, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. J. D. Burton, R. N. Bamford, C. Peters et al., “A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 11, pp. 4935–4939, 1994. View at Publisher · View at Google Scholar · View at Scopus
  5. V. Budagian, E. Bulanova, Z. Orinska et al., “Reverse signaling through membrane-bound interleukin-15,” The Journal of Biological Chemistry, vol. 279, no. 40, pp. 42192–42201, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. G. G. Neely, S. Epelman, L. L. Ma et al., “Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling,” Journal of Immunology, vol. 172, no. 7, pp. 4225–4234, 2004. View at Scopus
  7. S. Dubois, J. Mariner, T. A. Waldmann, and Y. Tagaya, “IL-15Rα recycles and presents IL-15 in trans to neighboring cells,” Immunity, vol. 17, no. 5, pp. 537–547, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Mortier, A. Quéméner, P. Vusio et al., “Soluble interleukin-15 receptor α (IL-15Rα)-sushi as a selective and potent agonist of IL-15 action through IL-15Rβ/γ: hyperagonist IL-15·IL-15Rα fusion proteins,” The Journal of Biological Chemistry, vol. 281, no. 3, pp. 1612–1619, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Mortier, J. Bernard, A. Plet, and Y. Jacques, “Natural, proteolytic release of a soluble form of human IL-15 receptor α-chain that behaves as a specific, high affinity IL-15 antagonist,” Journal of Immunology, vol. 173, no. 3, pp. 1681–1688, 2004. View at Scopus
  10. M. P. Rubinstein, M. Kovar, J. F. Purton et al., “Converting IL-15 to a superagonist by binding to soluble IL-15Rα,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 24, pp. 9166–9171, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Thalhamer, M. A. McGrath, and M. M. Harnett, “MAPKs and their relevance to arthritis and inflammation,” Rheumatology, vol. 47, no. 4, pp. 409–414, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. N. J. Chen, M. W. Huang, and S. L. Hsieh, “Enhanced secretion of IFN-γ by activated Th1 cells occurs via reverse signaling through TNF-related activation-induced cytokine,” Journal of Immunology, vol. 166, no. 1, pp. 270–276, 2001. View at Scopus
  13. I. B. McInnes, J. A. Gracie, M. Harnett, W. Harnett, and F. Y. Liew, “New strategies to control inflammatory synovitis: interleukin 15 and beyond,” Annals of the Rheumatic Diseases, vol. 62, no. 2, pp. 51–54, 2003. View at Scopus
  14. N. Oppenheimer-Marks, R. I. Brezinschek, M. Mohamadzadeh, R. Vita, and P. E. Lipsky, “Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells in vitro and in the SCID mouse-human rheumatoid arthritis model in vivo,” Journal of Clinical Investigation, vol. 101, no. 6, pp. 1261–1272, 1998. View at Scopus
  15. I. B. Mcinnes, B. P. Leung, R. D. Sturrock, M. Field, and F. Y. Liew, “Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis,” Nature Medicine, vol. 3, no. 2, pp. 189–195, 1997. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Ferretti, O. Bonneau, G. R. Dubois, C. E. Jones, and A. Trifilieff, “Il-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger,” Journal of Immunology, vol. 170, no. 4, pp. 2106–2112, 2003. View at Scopus
  17. W. A. Verri, T. M. Cunha, S. H. Ferreira et al., “IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production,” European Journal of Immunology, vol. 37, no. 12, pp. 3373–3380, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. M. E. Miranda-Carús, M. Benito-Miguel, A. Balsa et al., “Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes,” Arthritis and Rheumatism, vol. 54, no. 4, pp. 1151–1164, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Ogata, A. Kukita, T. Kukita et al., “A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2,” Journal of Immunology, vol. 162, no. 5, pp. 2754–2760, 1999. View at Scopus
  20. S. Djaafar, D. D. Pierroz, R. Chicheportiche, X. X. Zheng, S. L. Ferrari, and S. Ferrari-Lacraz, “Inhibition of T cell-dependent and RANKL-dependent osteoclastogenic processes associated with high levels of bone mass in interleukin-15 receptor-deficient mice,” Arthritis and Rheumatism, vol. 62, no. 11, pp. 3300–3310, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Santos, A. Cabrales, O. Reyes et al., “Identification of an interleukin-15 antagonist peptide that binds to IL-15Rα,” Biotecnología Aplicada, vol. 25, no. 4, pp. 320–324, 2008. View at Scopus
  22. T. Thalhamer, M. A. McGrath, and M. M. Harnett, “MAPKs and their relevance to arthritis and inflammation,” Rheumatology, vol. 47, no. 4, pp. 409–414, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Emery, E. Keystone, H. P. Tony et al., “IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial,” Annals of the Rheumatic Diseases, vol. 67, no. 11, pp. 1516–1523, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. E. W. Thurkow, I. M. Van Der Heijden, F. C. Breedveld et al., “Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis,” Journal of Pathology, vol. 181, no. 4, pp. 444–450, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Musso, L. Calosso, M. Zucca et al., “Human monocytes constitutively express membrane-bound, biologically active, and interferon-γ-upregulated interleukin-15,” Blood, vol. 93, no. 10, pp. 3531–3539, 1999. View at Scopus
  26. H. Kobayashi, S. Dubois, N. Sato et al., “Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance,” Blood, vol. 105, no. 2, pp. 721–727, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. N. J. Zvaifler, “The immunopathology of joint inflammation in rheumatoid arthritis,” Advances in Immunology, vol. 16, pp. 265–336, 1973. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Matsumoto, T. Tsurumoto, and H. Shindo, “Interleukin-6 levels in synovial fluids of patients with rheumatoid arthritis correlated with the infiltration of inflammatory cells in synovial membrane,” Rheumatology International, vol. 26, no. 12, pp. 1096–1100, 2006. View at Publisher · View at Google Scholar · View at Scopus