Table 1: Demographic and clinical characteristics of the outpatients with knee OA.

Set 1 patients“Low mTOR” subset ( )“High mTOR” subset ( ) (Student’s unpaired -test)

Age, years 0.86
Disease duration, years 0.80
BMI, kg/m2 0.06
Menopause, years 0.69
Average K&L radiological stage
 II46.6% (7/15)68% (22/32)0.15
 III40% (6/15)18.7% (6/15)0.16
 IV13.4% (2/15)12.5% (4/32)0.93
ESR, mm/h 0.55
Total WOMAC, mm 0.29
Pain on descending 0.28
Pain on ascending 0.35
Pain on move onset 0.64
Pain at rest 0.55
Pain on walking 0.009
Pain on standing 0.02
Pain at night 0.34
Total pain 0.26
Total stiffness 0.003
Total physical function 0.55
Heberden’s nodes, %80.0 (12/15)59.0 (19/32)0.08
Bouchard’s nodes, %27.0 (4/15)18.7 (6/32)0.26
Synovitis, %20 (3/15)62.5 (20/32)0.004
BMD, g/cm2:
 Lumbar spine (L1–L4) 0.35
 Femoral neck 0.16
 Total femur 0.01
Anti-inflammatory treatment (%):
 Meloxicam53 (8/15)72 (23/32)0.20
 Nimesulide27 (4/15)22 (7/32)0.70
 Aceclofenac06 (2/32)
 None20 (3/15)0
Chondroprotective agents (%):
 Chondroitin sulfate60 (9/15)22 (7/32)0.01
 Chondroitin sulfate + glucosamine sulphate40 (6/15)78 (25/32)0.01

Values given are mean SD. BMI: body mass index; K&L: Kellgren-Lawrence; ESR: erythrocyte sedimentation rate; WOMAC: Western Ontario and McMaster Universities osteoarthritis index; BMD: bone mineral density.