Table 2: Correlation coefficients (Pearson’s) and their significance ( ; Student’s unpaired -test) are shown for the expression of mTOR, ULK1, p21,  caspase 3, and TNFα genes in OA patients and healthy subjects in relation to each other and clinical traits.

Set 1 patientsmTOR ULK1 Caspase  3 TNFα

Low mTOR” subset
OA patients ( )
Caspase 3 0.645 
 Pain on walking
 Pain on standing
 Total physical function   
 Total WOMAC

 BMD L1–L4
0.544 
 BMD total femur0.580 

“High mTOR” subset
OA patients
( )
 mTOR 0.369 
0.408 
0.691 
21 0.360 
0.683 
0.354 
  Caspase 30.502 
 BMI
0.432 
 BMD L1–L4
0.454 
 BMD femoral neck0.439 
 ESR0.442 

End-stage OA patients
( )
 mTOR 0.549 
 ULK1 0.813 
21 0.770 
0.756 

Healthy subjects
TNFα
0.639 
0.556 

Only significant data are presented. ESR: erythrocyte sedimentation rate; WOMAC: Western Ontario and McMaster Universities osteoarthritis index; BMD: bone mineral density; BMI: body mass index.