Table 2: Statistically significant associations in group with early knee OA (grade = 1) with ADAM12 gene SNPs (were observed only for rs1044122).

Grade 0Grade 1OR (95% CI)P valueCorrected P value**

Rs1044122, whole groupOA in TFJ

A allele61%68%1.37 (1.01–1.87)0.0420.087
AA82 (39%)79 (43%)2.43 (1.17–5.05)0.0170.036
AG93 (45%)92 (50%)3.26 (1.10–4.62)0.0260.054
GG34 (16%)14 (7%)1*1*

Rs1044122, femalesOA in TFJ

A allele60%70%1.63 (1.12–2.37)0.0180.038
AA53 (37%)58 (44%)3.78 (1.5–9.54)0.0050.010
AG66 (46%)65 (50%)2.92 (1.18–7.23)0.0210.043
GG24 (17%)8 (6%)1*1*

Rs1044122, femalesOPH in TFJ

A allele60%70%1.57 (1.08–2.29)0.0180.038
AA61 (37%)50 (45%)3.81 (1.42–10.23)0.0080.017
AG76 (47%)56 (50%)3.09 (1.17–8.16)0.0230.048
GG26 (16%)6 (5%)1*1*

OA in TFJ: radiographic osteoarthritis in tibiofemoral joint; OPH in TFJ: osteophytes in tibiofemoral joint; GG genotypes were analysed as base; for multiple comparison correction Benjamini and Yekutieli method was used; in bold are shown statistically significant P values.