Table 3: Statistically significant association of rs1871054 in ADAM12 gene with advanced (grade ≥ 2) knee radio features (were found only on males).

Grade 0 Grade ≥ 2OR (95% CI)P valueCorrected P value**

rs1871054, malesOA

C allele44%68%2.82 (1.20–6.67)0.0180.038
CC8 (16%)10 (50%)7.86 (1.30–47.69)0.0250.052
CT29 (57%)7 (35%)1.39 (0.28–7.02)NS
TT14 (27%)3 (15%)1*1*

rs1871054, malesOPH

C allele45%70%2.67 (1.11–6.44)0.0290.06
CC11 (18%)8 (61%)5.31 (0.94–29.87)NS
CT33 (55%)5 (38%)1.01 (0.19–5.48)NS
TT16 (27%)3 (23%)1*1*

rs1871054, malesOA in TFJ

C allele48%73% 3.82 (1.36–10.73)0.0110.023
CC12 (18%)8 (62%)10.11 (1.29–79.45)0.0280.058
CT35 (53%)3 (23%)1.26 (0.17–9.54)NS
TT19 (29%)2 (15%)1*1*

rs1871054, malesOPH in TFJ

C allele 47%73 %3.03 (1.11–7.53)0.0180.038
CC 15 (20%)8 (53%)6.63 (1.15–38.17)0.0340.07
CT 39 (53%)5 (323%)1.66 (0.30–9.40)NS
TT 20 (27%)2 (15%)1*1*

OA: global grade of radiographic knee OA in tibiofemoral joint and/or patellofemoral joint; TFJ: tibiofemoral joint; OPH: osteophytes; TT genotypes were analysed as base; for multiple comparison correction Benjamini and Yekutieli method was used; in bold are shown statistically significant P values.