Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population

Table 4

The genetic association of ADAM12 haplotype (rs3740199, rs1871054, rs1272278, and rs1044122) and radiographic knee OA features.

Haplotype	Features	Grade 0^†	Grade ≥ 2^††	P value	sim P value*
CCAA, whole group	OA in TFJ	1.4%	5.6%	0.005	0.024
	OPH	1.4%	3.8%	0.018	0.040
	OPH in TFJ	1.4%	5.5%	0.004	0.030
CCAA, males	OA in TFJ	1.9%	15%	0.0001	0.014
	OPH	1.3%	11%	0.005	0.028
	OPH inTFJ	1.2%	15%	0.0001	0.014
GCGG, females	JSN	19%	43%	0.040	0.048

OA: radiographic osteoarthritis in tibiofemoral joint (TFJ); OPH: osteophytes; JSN: joint space narrowing; †calculated haplotype frequencies in subjects with no radiographic changes (grade 0); ††calculated haplotype frequencies in subjects with late radiographic knee OA features; ∗by 10 000 simulations.