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Arthritis
Volume 2014 (2014), Article ID 159089, 8 pages
http://dx.doi.org/10.1155/2014/159089
Review Article

Zingiber officinale: A Potential Plant against Rheumatoid Arthritis

1Department of Pharmacy, University of Development Alternative, Dhanmondi, Dhaka 1209, Bangladesh
2Department of Biotechnology and Genetic Engineering, University of Development Alternative, Dhaka 1209, Bangladesh

Received 4 March 2014; Revised 28 April 2014; Accepted 13 May 2014; Published 27 May 2014

Academic Editor: Shinichi Kawai

Copyright © 2014 Abdullah Al-Nahain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease particularly affecting elderly people which leads to massive bone destruction with consequent inflammation, pain, and debility. Allopathic medicine can provide only symptomatic relief. However, Zingiber officinale is a plant belonging to the Zingiberaceae family, which has traditionally been used for treatment of RA in alternative medicines of many countries. Many of the phytochemical constituents of the rhizomes of this plant have therapeutic benefits including amelioration of RA. This review attempts to list those phytochemical constituents with their reported mechanisms of action. It is concluded that these phytochemicals can form the basis of discovery of new drugs, which not only can provide symptomatic relief but also may provide total relief from RA by stopping RA-induced bone destruction. As the development of RA is a complex process, further research should be continued towards elucidating the molecular details leading to RA and drugs that can stop or reverse these processes by phytoconstituents of ginger.