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Arthritis
Volume 2014 (2014), Article ID 503519, 8 pages
http://dx.doi.org/10.1155/2014/503519
Research Article

Quantitative Gait Analysis Detects Significant Differences in Movement between Osteoarthritic and Nonosteoarthritic Guinea Pig Strains before and after Treatment with Flunixin Meglumine

1Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
2Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
3Department of Veterinary Preventative Medicine, The Ohio State University, Columbus, OH 43210, USA
4Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH 43210, USA

Received 10 February 2014; Revised 10 April 2014; Accepted 17 April 2014; Published 19 May 2014

Academic Editor: Changhai Ding

Copyright © 2014 K. S. Santangelo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A computer-aided gait analysis system was used to contrast two guinea pig strains with differing propensity for osteoarthritis (OA), with/without administration of a nonsteroidal anti-inflammatory drug. Walking speed and static/dynamic gait parameters were determined at baseline. Flunixin meglumine was given and animals were evaluated 4, 24, and 72 hours after treatment. Body weight was compared using unpaired -tests. Knee joints were histologically evaluated using species-specific criteria; indices were analyzed using one-way ANOVA, Kruskal-Wallis test, followed by Dunn’s multiple comparisons. A generalized linear model followed by Tukey’s posttests juxtaposed gait parameters; walking speed was a covariate for other outcome measures. Body weight was not different between strains; OA-prone animals demonstrated more progressive chondropathy. At baseline, OA-prone animals had slower walking speeds, narrower hind limb bases of support, shorter stride lengths, and slower limb swing speeds relative to OA-resistant animals. These differences were not detected 4 or 24 hours after treatment. By 72 hours, OA-prone animals had returned to baseline values. These findings indicate a distinct voluntary gait pattern in a rodent model of bilateral primary OA, modification of which may allow rapid screening of novel therapies. Flunixin meglumine temporarily permitted OA-prone animals to move in a manner that was analogous to OA-resistant animals.