Chemical Exposure Generates DNA Copy Number Variants and Impacts Gene Expression

Table 6

Gene ontology analysis for enrichment of biological function with 2 mM EMS treatment.

Biological function	value^a	Number of genes^b
Diseases and disorders
Developmental disorder		177
Skeletal and muscular; disorders		66
Infectious disease		170
Connective tissue; disorder		40
Cardiovascular disease		43
Molecular and cellular functions
Cellular movement		204
Amino acid metabolism		78
Small molecule; biochemistry		183
Cellular assembly and; organization		179
Cellular function and; maintenance		189
Physiological system development and function
Tissue morphology		209
Organismal survival		187
Embryonic development		221
Organismal development		284
Organ morphology		143

Derived from the likelihood of observing the degree of enrichment in a gene set of a given size by chance alone. A maximum false discovery rate of 5% was accepted in this analysis.
Classified as being differentially expressed that relate to the specified function category; a gene may be present in more than one category.