Chemical Exposure Generates DNA Copy Number Variants and Impacts Gene Expression

Table 7

Genes with altered expression mapping within CNVs in the 2 mM EMS treatment.

CNV region			Gene expression array data
Chromosome	Genomic region	Gain/loss	Chromosome	Genomic region	Sequence ID	Fold change	Human gene	Gene symbol
6	49556168–50808094	Loss	6	49674955–49688887	ENSDART00000002693	−5.037	Syntaxin 16	STX16
			6	49947447–49963592	BC066706.1	−2.129	Eukaryotic translation initiation factor 2, subunit 2 beta	EIF2S
8	32921651–33404812	Loss	8	32982721–32982807	NM_001039461	−6.194	Mediator complex subunit 12	MED12
18	31915173–33340460	Loss	18	32385597–32398337	NM_201108	−5.699	Solute carrier family 33 (acetyl-CoA transporter), member 1	SLC33A1
			18	32408894–32442474	NM_200587	−13.404	Guanine monophosphate synthetase	GMPS
21	8967733–9185499	Gain	21	9178136–9675872	ENSDART00000054092	−9.299	AT rich interactive domain 5B (MRF1-like)	ARID5B
21	21053248–21398259	Loss	21	21135672–21166560	NM_001080007	−3.236	Calpain 5	CAPN5