Table 1: Quality-of-life instruments. (With permission from Lee et al. [44]).

InstrumentInstitutionDomainsValidatedReliableCancer specificBladder cancer specificNo. of items

BCI [33, 45]University of MichiganUrinary
Bowel
Sexual function
YesYesYesYes34
FACT-VCI [46]Vanderbilt UniversitySee FACT-G
Urinary
Bowel
Sexual function
YesYesYesYes (limited tocystectomy)45
QLQ-BLM 30 module [47]EORTCUrinary
Bowel
Sexual function
Ongoing studiesOngoing studiesYesYes (muscle-invasive disease)30
QLQ-BLS 24 Module [45]EORTCUrinary
Bowel
Sexual function
Ongoing studiesOngoing studiesYesYes (nonmuscle-invasive disease)24
FACT-BL [48]FACITSee FACT-G
Limited urinary
Limited bowel
Limited sexual function
Ongoing studiesOngoing studiesYesYes39

FACT-G [49]FACITPhysical
Social
Emotion
Function
YesYesYesNo27
QLQ-C30 [47]EORTC5 Functional scales
3 Symptom scales
1 Global health/QOL scale
YesYesYesNo30

SF-36 [34]RAND8 Domains including
Physical
Mental
Social function
Emotional
YesYesNoNo36

BCI: Bladder Cancer Index; EORTC: European Organization for the Research and Treatment of Cancer.
FACIT: The Functional Assessment of Chronic Illness Therapy.
FACT-BL: Functional Assessment of Cancer Therapy—Bladder Cancer (Extension of the FACT-G + 12 additional bladder cancer-specific items including incontinence, diarrhea, body image, sexual function, and stoma care).
FACT-G: Functional Assessment of Cancer Therapy General.
FACT-VCI: Functional Assessment of Cancer Therapy—Vanderbilt Cystectomy Index (Extension of the FACT-G + 17 additional bladder cancer and treatment specific items).
QLQ-C30: EORTC Quality-of-Life Core Questionnaire.
QLQ-BLM30: EORTC Quality-of-Life Core Questionnaire—Bladder Cancer Muscle Invasive (Extension of the QLQ-C30 + 30 additional bladder cancer-specific items; http://www.eortc.be/home/qol/files/SCManualQLQ-C30.pdf).
QLQ-BLS24: EORTC Quality-of-Life Core Questionnaire—Bladder Cancer Superficial (Extension of the QLQ-C30 + 24 additional bladder cancer-specific items; http://www.eortc.be/home/qol/files/SCManualQLQ-C30.pdf).
RAND Corporation: Research ANd Development.
SF-36: Medical Outcomes Study 36-Item Short Form.