Clinical Results after High-Dose Intensity-Modulated Radiotherapy for High-Risk Prostate Cancer

Table 1

(a) The in-house developed Gastrointestinal toxicity scale, (b) The in-house developed Genitourinary toxicity scale.

(a)

GI	Grade 1	Grade 2	Grade 3	Grade 4
Abdominal cramps	Present, no therapy	Peroral therapy, for example, Spasmolytic	IV therapy	Surgery
Diarrhea	Present, no therapy	Peroral therapy, for example, loperamide	IV therapy	Surgery
Frequency	Present, no therapy	Peroral therapy, for example, loperamide	IV therapy	—
Mucus loss	Present, no therapy	Need hygienic pads	Continuous, invasive therapy	Surgery
Red blood loss	No therapy, frequency < 3x/week	Frequency ≥ 3x/week	Invasive therapy needed, for example, laser coagulation	Transfusion need, surgery
Urgency	Present, no therapy	Peroral therapy	IV therapy	—
Incontinence	Present, no therapy	Need hygienic pads (≤2/day)	Need hygienic pads (>2/day)	Surgery
Anal pain	Present, no therapy	Local anesthetic for example, Xylogel	Narcotic analgetica	Surgery

(b)

GU	Grade 1	Grade 2	Grade 3	Grade 4
Nocturia	Twice pretherapy, 2-3 times	4–6 times (<1x hour)	>6 times (more frequently than hourly)	—
Frequency	Once/2 h, twice pretherapy	Once/1 h	Once/0.5 h (more frequent than hourly)	—
Hematuria	Microscopic	Intermittent/moderate	Frequent, gross hematuria/minor surgery needed (coagulation)	Hemorrhagic cystitis requiring transfusion/; ulceration/; necrosis
Dysuria	Slight, no medication	Moderate, requiring local anesthetic (including bladder spasm)	Dysuria, regular and frequent narcotics needed (including bladder spasm and pelvis pain)/severe/; stenosis/TUR or; dilatation	Bladder obstruction not secondary to clot passage
Urgency	Slight, no medication	Moderate, requiring local anesthetic (including bladder spasm)	Severe requiring local anesthetic	—
Incontinence	<weekly episodes	<daily episodes	Pads/undergarments/; day	Refractory