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Advances in Urology
Volume 2012 (2012), Article ID 429213, 10 pages
http://dx.doi.org/10.1155/2012/429213
Review Article

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges

1Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James’s University Hospital, Leeds LS9 7TF, UK
2Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK

Received 31 May 2012; Accepted 17 June 2012

Academic Editor: Nan-Haw Chow

Copyright © 2012 Erica di Martino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [25 citations]

The following is the list of published articles that have cited the current article.

  • S. V. Williams, C. D. Hurst, and M. A. Knowles, “Oncogenic FGFR3 gene fusions in bladder cancer,” Human Molecular Genetics, vol. 22, no. 4, pp. 795–803, 2012. View at Publisher · View at Google Scholar
  • C. G. Stoehr, R. Stoehr, A. Rogler, K. Amann, R. Knuechel-Clarke, and A. Hartmann, “Personalized urooncology based on molecular uropathology. Part 1: What is diagnostic routine?,” Urologe, vol. 52, no. 7, pp. 970–975, 2013. View at Publisher · View at Google Scholar
  • Shirish M. Gadgeel, Wei Chen, Michele L. Cote, Aliccia Bollig-Fischer, Susan Land, Ann G. Schwartz, and Gerold Bepler, “Fibroblast Growth Factor Receptor 1 Amplification in Non-Small Cell Lung Cancer by Quantitative Real-Time PCR,” Plos One, vol. 8, no. 11, 2013. View at Publisher · View at Google Scholar
  • Artur A. Belov, and Moosa Mohammadi, “Molecular Mechanisms of Fibroblast Growth Factor Signaling in Physiology and Pathology,” Cold Spring Harbor Perspectives In Biology, vol. 5, no. 6, 2013. View at Publisher · View at Google Scholar
  • Jaime Acquaviva, Suqin He, Chaohua Zhang, John-Paul Jimenez, Masazumi Nagai, Jim Sang, Manuel Sequeira, Donald L. Smith, Luisa Shin Ogawa, Takayo Inoue, Noriaki Tatsuta, Margaret A. Knowles, Richard C. Bates, and David A. Proia, “FGFR3 Translocations in Bladder Cancer: Differential Sensitivity to HSP90 Inhibition Based on Drug Metabolism,” Molecular Cancer Research, vol. 12, no. 7, pp. 1042–1054, 2014. View at Publisher · View at Google Scholar
  • Xiguang Zhang, Jiasen Xie, Yan Sun, Huijing Xu, Tonghua Du, Zixuan Liu, Jinhui Chen, Zhong Zheng, Keqiang Liu, Jizhou Zhang, Mujie Kan, Xiaokun Li, and Yechen Xiao, “High-level expression, purification, and characterization of bifunctional ScFv-9R fusion protein,” Applied Microbiology and Biotechnology, vol. 98, no. 12, pp. 5499–5506, 2014. View at Publisher · View at Google Scholar
  • Yann Neuzillet, Bas W. G. van Rhijn, Nadia L. Prigoda, Bharati Bapat, Liyang Liu, Peter J. Bostrom, Neil E. Fleshner, Brenda L. Gallie, Alexandre R. Zlotta, Michael A. S. Jewett, and Theo H. van der Kwast, “FGFR3 mutations, but not FGFR3 expression and FGFR3 copy-number variations, are associated with favourable non-muscle invasive bladder cancer,” Virchows Archiv, 2014. View at Publisher · View at Google Scholar
  • A. Hartmann, T. Schlomm, S. Bertz, J. Heinzelmann, S. Hölters, R. Simon, R. Stoehr, and K. Junker, “Prognostische und prädiktive molekulare Marker urologischer Tumoren,” Der Urologe, vol. 53, no. 4, pp. 491–500, 2014. View at Publisher · View at Google Scholar
  • Meilin Wang, Haiyan Chu, Qiang Lv, Li Wang, Lin Yuan, Guangbo Fu, Na Tong, Chao Qin, Changjun Yin, Zhengdong Zhang, and Jianfeng Xu, “Cumulative effect of genome-wide association study-identified genetic variants for bladder cancer,” International Journal of Cancer, 2014. View at Publisher · View at Google Scholar
  • Nicole Schweiger, Marlene Hauck, Heinrich Steinhoff, Sandra Sampl, Martin Reifinger, Ingrid Walter, Theresa Kreilmeier, Brigitte Marian, Michael Grusch, Walter Berger, Klaus Holzmann, and Miriam Kleiter, “Canine and human sarcomas exhibit predominant FGFR1 expression and impaired viability after inhibition of signaling,” Molecular Carcinogenesis, 2014. View at Publisher · View at Google Scholar
  • Caroline J. Sheeba, Gregory Marslin, Ann Mary Revina, and Gregory Franklin, “Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery,” Nanotechnology Reviews, vol. 3, no. 2, pp. 123–151, 2014. View at Publisher · View at Google Scholar
  • Deyao Wu, Yunfeng Zhou, Huixing Pan, Jian Zhou, Yuanfeng Fan, and Ping Qu, “microRNA-99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer,” Oncology Letters, vol. 7, no. 4, pp. 1219–1224, 2014. View at Publisher · View at Google Scholar
  • Rosa Nadal, “New Treatments for Bladder Cancer: When Will We Make Progress?,” Current Treatment Options in Oncology, vol. 15, no. 1, pp. 99–114, 2014. View at Publisher · View at Google Scholar
  • Benedito A. Carneiro, Joshua J. Meeks, Timothy M. Kuzel, Mariana Scaranti, Sarki A. Abdulkadir, and Francis J. Giles, “Emerging therapeutic targets in bladder cancer,” Cancer Treatment Reviews, 2014. View at Publisher · View at Google Scholar
  • Li Peng, Xiu Wu Bian, Di Kang Li, Chuan Xu, Guang Ming Wang, Qing You Xia, and Qing Xiong, “Large-scale RNA-Seq Transcriptome Analysis of 4043 Cancers and 548 Normal Tissue Controls across 12 TCGA Cancer Types,” Scientific Reports, vol. 5, pp. 13413, 2015. View at Publisher · View at Google Scholar
  • Teresa Helsten, Maria Schwaederle, and Razelle Kurzrock, “Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications,” Cancer and Metastasis Reviews, 2015. View at Publisher · View at Google Scholar
  • Zixuan Liu, Jizhou Zhang, Hongqiong Fan, Ruofeng Yin, Zhong Zheng, Qian Xu, Qing Liu, Haiting He, Xiaofan Peng, XinXin Wang, Xiaokun Li, and Yechen Xiao, “Expression and purification of soluble single-chain Fv against human fibroblast growth factor receptor 3 fused with Sumo tag in Escherichia coli,” Electronic Journal of Biotechnology, 2015. View at Publisher · View at Google Scholar
  • Francesco Massari, Matteo Santoni, Chiara Ciccarese, Matteo Brunelli, Alessandro Conti, Daniele Santini, Rodolfo Montironi, Stefano Cascinu, and Giampaolo Tortora, “Emerging concepts on drug resistance in bladder cancer: Implications for future strategies,” Critical Reviews in Oncology/Hematology, 2015. View at Publisher · View at Google Scholar
  • Nathalie Javidi-Sharifi, Elie Traer, Jacqueline Martinez, Anu Gupta, Takehiro Taguchi, Jennifer Dunlap, Michael C. Heinrich, Christopher L. Corless, Brian P. Rubin, Brian J. Druker, and Jeffrey W. Tyner, “Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance,” Cancer Research, vol. 75, no. 5, pp. 880–891, 2015. View at Publisher · View at Google Scholar
  • Paul Kachel, Bogusz Trojanowicz, Carsten Sekulla, Hanna Prenzel, Henning Dralle, and Cuong Hoang-Vu, “Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase a by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue,” BMC Cancer, vol. 15, no. 1, 2015. View at Publisher · View at Google Scholar
  • Bishoy M Faltas, Beerinder S Karir, Scott T Tagawa, and Jonathan E Rosenberg, “Novel molecular targets for urothelial carcinoma,” Expert Opinion on Therapeutic Targets, pp. 1–11, 2015. View at Publisher · View at Google Scholar
  • Erica di Martino, Gavin Kelly, Jo-An Roulson, and Margaret A. Knowles, “Alteration of Cell-Cell and Cell-Matrix Adhesion in Urothelial Cells: An Oncogenic Mechanism for Mutant FGFR3,” Molecular Cancer Research, vol. 13, no. 1, pp. 138–148, 2015. View at Publisher · View at Google Scholar
  • Anna Fischbach, Anja Rogler, Ramona Erber, Robert Stoehr, Richard Poulsom, Axel Heidenreich, Birte-Swantje Schneevoigt, Sven Hauke, Arndt Hartmann, Ruth Knuechel, Jürgen Veeck, and Nadine T Gaisa, “Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer,” Histopathology, 2015. View at Publisher · View at Google Scholar
  • Qing-hai Wang, Zhi-Gang Ji, Zhi-gang Chen, Han-zhong Li, Hua Fan, Xin-rong Fan, Bing-bing Shi, and Yujiang Fang, “Serum CA 19-9 as a good prognostic biomarker in patients with bladder cancer,” International Journal of Surgery, 2015. View at Publisher · View at Google Scholar
  • Francesco Massari, Chiara Ciccarese, Matteo Santoni, Matteo Brunelli, Alessandro Conti, Alessandra Modena, Rodolfo Montironi, Daniele Santini, Liang Cheng, Guido Martignoni, Stefano Cascinu, and Giampaolo Tortora, “The route to personalized medicine in bladder cancer: where do we stand?,” Targeted Oncology, 2015. View at Publisher · View at Google Scholar