Management of High-Risk Localized Prostate Cancer

Table 1

Anatomic stage/prognostic groups, high-risk localized prostate cancer.

Group	T	N	M	PSA	Gleason
I	T1a–c	N0	M0	PSA < 10	Gleason ≤ 6
	T2a	N0	M0	PSA < 10	Gleason ≤ 6
	T1-2a	N0	M0	PSA X	Gleason X
IIA	T1a–c	N0	M0	PSA < 20	Gleason 7
	T1a–c	N0	M0	10 ≤ PSA < 20	Gleason ≤ 6
	T2a	N0	M0	10 ≤ PSA < 20	Gleason ≤ 6
	T2a	N0	M0	PSA < 20	Gleason 7
	T2b	N0	M0	PSA < 20	Gleason ≤ 7
	T2b	N0	M0	PSA X	Gleason X
IIB	T2c	N0	M0	Any PSA	Any Gleason
	T1-2	N0	M0	PSA ≥ 20	Any Gleason
	T1-2	N0	M0	Any PSA	Gleason > 8
III	T3a-b	N0	M0	Any PSA	Any Gleason
IV	T4	N0	M0	Any PSA	Any Gleason
	Any T	N1	M0	Any PSA	Any Gleason
	Any T	Any N	M1	Any PSA	Any Gleason

Adapted from American Joint Committee on Cancer (AJCC Cancer Staging Manual, Seventh Edition, 2010).