Review Article
Management of High-Risk Localized Prostate Cancer
Table 4
Summary of randomized control trials involving chemotherapy for high-risk localized prostate cancer.
| Study (reference) | Chemo sequencing | Chemo regimen | Study arms | Number of patients | High-risk criteria | Stage | Gleason | PSA |
|
RTOG 9902 [14] | Adjuvant | paclitaxel estramustinee toposide (TEE) | ADT + RT versus ADT + RT + TEE | 397 | any T | ≥7 | 20–100 | ≥ T2 | 8–10 | <100 |
|
RTOG 0521 [15] | Adjuvant | Docetaxel | ADT + RT versus ADT + RT + docetaxel | 612 | any T | ≥9 | ≤150 | ≥ T2 | 8 | <20 | any T | 7-8 | ≥20–150 |
|
Kumar et al. [72] | Concurrent | Docetaxel | RT + docetaxel | 22 | T3-T4 | | | T1b-T2 | ≥8 | | T1c-T2 | 5–7 | ≥10 |
|
AGUSG 03-10 [73] | Concurrent | Docetaxel | RT + docetaxel +/− ADT | 20 | ≥T3 | 8–10 | | 7 | >10 |
| Sanfilippo et al. [74] | Concurrent | Paclitaxel | ADT + RT versus ADT + RT + paclitaxel | 22 | TxN1 | >7 | >10 |
| Hussain et al. [75] | Neoadjuvant | Docetaxel estramustine | docetaxel, EMP +/− RP, RT | 21 | ≥T2b | 8–10 | ≥15 |
| Hirano et al. [76] | Neoadjuvant/ concurrent | Estramustine | ADT + RT versus ADT + RT + EMP | 39 | ≥T3 | 8–10 | >20 |
| SWOG S9921 [77, 78] | Neoadjuvant | Mitoxantrone | RP + ADT versus RP + ADT + MTX | 983 | pT3b-T4 | ≥8 | | | 7 | >15 |
| CALGB 90203 [79] | Neoadjuvant | Estramustine docetaxel | RP versus EMP and docetaxel + RP | recruiting | T1-T3a, NX, M0 | | |
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ADT: androgen deprivation therapy; RT: radiotherapy; TEE: paclitaxel, estramustine, etoposide; EMP: estramustine phosphate; RP: radical prostatectomy; MTX: mitoxantrone.
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