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Advances in Urology
Volume 2012 (2012), Article ID 727843, 4 pages
http://dx.doi.org/10.1155/2012/727843
Clinical Study

The Effects of Local Administration of Aminophylline on Transureteral Lithotripsy

1Department of Urology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2Department of Anesthesiology, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran
3Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran

Received 26 May 2012; Revised 16 July 2012; Accepted 6 September 2012

Academic Editor: Maxwell V. Meng

Copyright © 2012 Ayyoub Barzegarnezhad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Urinary stone is a common cause of urinary tract disease. Stone excretion using ureteroscope is effective in inferior ureter. The aim of this study was to investigate the effects of aminophylline on ureteral spasm during ureteroscopy in acute phase of renal colic. Methods. In this double-blind randomized clinical trial, 120 patients with ureteral stones were enrolled and randomized into two groups. The bladder was drained and then received a 150 mL irrigation solution. Irrigation solution was saline and saline plus 10 mL aminophylline at 250 mg dose for control and case groups, respectively. Ureteroscopy and transureteral lithotripsy (TUL) were performed five minutes after irrigation. Results. The mean duration of TUL was  min and  min for control and case groups, respectively. The successful rate was 95% and 76.1% in case and control groups, respectively. Further extracorporeal shock wave lithotripsy (SWL) was performed in 5% and 30% for patients in case and control groups, respectively. Conclusion. Aminophylline facilitated ureteroscopy and increased the success rate in the treatment of renal colic using TUL. No significant complications from post-TUL were observed. Using aminophylline carries several advantages such as reducing procedure duration, decreasing the need for ureteral and double-J catheter, and reducing stone migration to the kidney and use of SWL.