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Advances in Urology
Volume 2013 (2013), Article ID 348438, 6 pages
http://dx.doi.org/10.1155/2013/348438
Research Article

Clinical Significance of Amyloid Precursor Protein in Patients with Testicular Germ Cell Tumor

1Department of Urology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
2Department of Urology, National Center of Global Health and Medicine, Shinjuku-ku, Tokyo, Japan
3Department of Urology, Nihon University, School of Medicine, Itabashi-ku, Tokyo, Japan
4Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
5Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
6Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Hidaka-shi, Saitama, Japan

Received 13 February 2013; Accepted 17 March 2013

Academic Editor: Maxwell V. Meng

Copyright © 2013 Yuta Yamada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. The biological role of amyloid precursor protein (APP) is not well understood, especially in testicular germ cell tumors (TGCTs). Therefore, we aimed to investigate the immunoreactivity (IR) and expression of APP in TGCTs and evaluated its clinical relevance. Materials and Methods. We performed an analysis of immunohistochemistry and mRNA expression of APP in 64 testicular specimens and 21 snap-frozen samples obtained from 1985 to 2004. We then evaluated the association between APP expression and clinicopathological status in TGCTs. Results. Positive APP IR was observed in 9.8% (4/41) of seminomatous germ cell tumors (SGCTs) and 39.1% (9/23) of nonseminomatous germ cell tumors (NGCTs). NGCTs showed significantly more cases of positive IR and a higher mRNA expression level compared with those of SGCTs . Positive APP IR was also significantly associated with α-fetoprotein (αFP) elevation and venous invasion . Conclusion. We observed an elevated APP expression in TGCTs, especially in NGCTs. APP may be associated with a more aggressive cancer in TGCTs.