Table 2: Relationships between APP immunoreactivity and clinicopathological characteristics in TGCT patients ( ).

Clinicopathological dataAPP immunoreactivity
Negative ( )Positive ( )P value

Age (years ± SD)36.5 ± 10.730.0 ± 15.80.182
Tumor marker
LDH0.340
High207
Normal316
αFP0.00870
High149
Normal374
βhCG0.844
High297
Normal226
IGCCC0.222
Good61
Intermediate23
Poor00
Stage
T stage0.0978
T1366
T2–4157
N stage0.444
N0439
N1–383
Unknown01
Venous invasion0.0414
Positive75
Negative448
Pathology0.0001
Benign testicular lesion310
SGCT374
NGCT149
Compared histological
types
SGCT versus NGCT0.00870
SGCT versus benign
testicular lesion
0.129
NGCT versus benign
testicular lesion
0.0002

APP: amyloid precursor protein, TGCT: testicular germ cell tumor, LDH: lactate dehydrogenase, αFP: alpha fetoprotein, βhCG: human chorionic gonadotropin β subunit, IGCCC: International Germ Cell Consensus Classification, SGCT: seminomatous germ cell tumor, NGCT: nonseminomatous germ cell tumor.