Table 1: Descriptive statistics by UUI status and results of separate bivariate logistic regression models with outcome of those having UUI. Results reported separately for the SISTEr and TOMUS trials.

CovariateSISTEr ( )TOMUS ( )
Yes ( )No ( ) valueOR
(95% CI)
Yes ( )No ( ) valueOR
(95% CI)

Menopausal status/hormone replacement therapy 0.0020.01
 No HRT, Postmenopausal178 (39%)53 (27%)1169 (42%)74 (39%)1
 Yes HRT, Postmenopausal156 (34%)67 (34%)0.69 (0.46–1.05)126 (31%)44 (23%)1.25 (0.81–1.94)
 Premenopausal120 (26%)76 (39%)0.47 (0.31–0.72)106 (26%)72 (38%)0.64 (0.43–0.97)
Prior to UI surgery and/or treatment0.010.19
 No 206 (45%)110 (56%)165 (41%)89 (47%)
 Yes249 (55%)86 (44%)1.55 (1.10–2.17)236 (59%)101 (53%)1.26 (0.89–1.78)
Prior to hysterectomy0.090.03
 No 306 (67%)145 (74%)276 (69%)147 (77%)
 Yes149 (33%)51 (26%)1.38 (0.95–2.01)125 (31%)43 (23%)1.55 (1.04–2.31)
Race/ethnicity0.160.06
 Hispanic56 (12%)15 (8%)1.79 (0.98–3.27)53 (13%)17 (9%)1.66 (0.93–2.95)
 Non-Hispanic white323 (71%)155 (79%)1307 (76%)163 (86%)1
 Non-Hispanic black34 (7%)10 (5%)1.63 (0.79–3.39)14 (3%)3 (2%)2.48 (0.70–8.75)
 Non-Hispanic other41 (9%)16 (8%)1.23 (0.67–2.26)29 (7%)7 (4%)2.20 (0.94–5.13)
Parity0.680.48
 No pregnancies16 (5%)6 (4%)117 (6%)8 (5%)1
 One pregnancy25 (7%)14 (10%)0.67 (0.21–2.10)37 (12%)27 (18%)0.64 (0.24–1.71)
 Two pregnancies112 (33%)49 (36%)0.86 (0.32–2.32)111 (37%)51 (34%)1.02 (0.42–2.53)
 Three or more pregnancies185 (55%)69 (50%)1.01 (0.38–2.67)133 (45%)65 (43%)0.96 (0.39–2.35)
Education0.002<.0001
48 (11%)6 (3%)125 (6%)8 (4%)1
 High school/GED115 (25%)56 (29%)0.26 (0.10–0.64)109 (27%)39 (21%)0.89 (0.37–2.15)
188 (41%)70 (36%)0.34 (0.14–0.82)160 (40%)57 (30%)0.90 (0.38–2.11)
 BA/BS56 (12%)42 (21%)0.17 (0.07–0.43)49 (12%)52 (27%)0.30 (0.12–0.73)
 Grad/Prof48 (11%)22 (11%)0.27 (0.10–0.73)60 (15%)34 (18%)0.56 (0.23–1.39)
Prolapse stage10.34
 Stage 0 or 1110 (24%)48 (24%)1189 (47%)77 (41%)1
 Stage 2271 (60%)116 (59%)1.02 (0.68–1.53)183 (45%)96 (51%)0.78 (0.54–1.12)
 Stage 3+74 (16%)32 (16%)1.01 (0.59–1.72)31 (8%)17 (9%)0.74 (0.39–1.42)
UI Severity (PGI-S)*N/A0.001
 Normal38 (9%)23 (12%)1
 Mild30 (7%)30 (16%)0.61 (0.29–1.25)
 Moderate202 (50%)97 (51%)1.26 (0.71–2.23)
 Severe132 (33%)39 (21%)2.05 (1.09–3.84)
Depression (PHQ-9)*N/A0.0001
 <10293 (74%)165 (88%)1
 10+ (defined as depression)103 (26%)22 (12%)2.64 (1.60–4.34)
Charlson Comorbidity Index (CCI)*N/A0.03
 0287 (71%)153 (81%)1
 169 (17%)27 (14%)1.36 (0.84–2.22)
 2+47 (12%)10 (5%)2.51 (1.23–5.10)

Mean (SD)Mean (SD)Mean (SD)Mean (SD)

UDI stress score (UDI-S)79.8 (20.2)73.8 (25.0)0.0021.13 (1.05–1.22)75.4 (20.6)72.5 (23.1)0.131.06 (0.98–1.15)
MESA stress score20.2 (4.1)17.2 (5.0)<0.00011.15 (1.11–1.20)20.0 (4.2)17.9 (5.0)<.00011.11 (1.06–1.15)
Age (years)52.2 (10.1)51.4 (10.8)0.371.08 (0.92–1.27)53.6 (10.9)51.3 (10.9)0.021.21 (1.03–1.43)
Body mass index30.4 (6.3)28.9 (5.4)0.0031.05 (1.02–1.08)30.7 (7.0)29.5 (6.2)0.031.03 (1.00–1.06)
IIQ total190.7 (100.7)126.3 (87.7)<0.00011.07 (1.05–1.09)169.4 (98.2)113.4 (83.4)<.00011.07 (1.05–1.09)
Pad weight (g)48.6 (87.6)31.3 (54.1)0.011.04 (1.01–1.08)38.1 (66.9)31.5 (66.6)0.271.02 (0.99–1.05)

UI severity, depression, and number of comorbidities were not collected in the SISTEr trial.