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Advances in Urology
Volume 2013 (2013), Article ID 929620, 5 pages
http://dx.doi.org/10.1155/2013/929620
Research Article

-DTPA Study to Validate an Experimental Model of Ureteral Obstruction in Rabbits: Preliminary Results

1Division of Urology, Department of Surgery, Campinas State University, Avenida Vital Brasil 251, Caixa Postal 6142, Cidade Universitária Zeferino Vaz, 13083-888 Campinas, SP, Brazil
2Nuclear Medicine Division, Department of Radiology, Campinas State University, Avenida Vital Brasil 251, Caixa Postal 6142, Cidade Universitária Zeferino Vaz, 13083-888 Campinas, SP, Brazil

Received 25 June 2013; Revised 11 October 2013; Accepted 15 October 2013

Academic Editor: Maxwell V. Meng

Copyright © 2013 Marcelo Lopes de Lima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To create a ureteral obstruction experimental model that can be proved through -DTPA renal scintigraphy and histopathological studies, without causing total renal function loss. Materials and Methods. Ten New Zealand white rabbits were submitted to a surgical experiment to create a model of unilateral obstruction to urinary flow. Surgery procedure provided unilateral ureteral obstruction (left kidney) to urinary flow and posteriorly was evaluated by -DTPA renal scintigraphy and histopathological study. -DTPA renal study was performed to detect and quantify signs of obstruction and to evaluate renal function. Statistical analysis was performed through the Student -test with a significance level of . Results. Nine of the ten rabbits presented left renal unit obstruction and one nonobstructive on the -DTPA and histopathological studies. All the right renal units, which were not submitted to surgical procedure, were nonobstructed by the studies. There was a general agreement between scintigraphy and histopathological results in both groups. Conclusion. The experimental model promoted the creation of ureteral obstruction in rabbits, confirmed by nuclear medicine scintigraphy and histopathology, and could be used in further studies to better understand urinary obstruction.