Table 2: Nested variant of urothelial carcinoma: example of results and geographic distribution of several markers in nested variant of urothelial carcinoma taken from Lin O, Cardillo M, Dalbagni G, Linkov I, Hutchinson B, and Reuter V E. Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. Modern Pathology 2003; 16(12): 1289–1298.

Case Ref.P21 resultP21 locationP27 resultP27 locationP53 resultP53 locationEGF-R resultBc12 resultBc12 locationMIB-1%MIB1 locationOther comments

1Lin et al. [7]+Diffuse+Surface20Diffuse

2Lin et al. [7]+Diffuse+Diffuse 15Diffuse

3Lin et al. [7]+Diffuse35Diffuse

4Lin et al.[7]+Diffuse+Surface35Diffuse

5Lin et al. [7]+Base+Surface+Base+Surface 2Base

6Lin et al. [7]+Surface20Diffuse

7Lin et al. [7] +Base+Surface+Surface35Diffuse

8Lin et al. [7]+Base+Surface15Base

9Lin et al. [7]+Surface+Diffuse30Diffuse

10Lin et al. [7]+Diffuse+Surface30Base

11Lin et al. [7]+Base+Surface20Diffuse

12Lin et al. [7]+Base+Surface+Base15Base

13Wang et al. [11]Not doneNot doneNot doneNot doneNot done

14Tatsura et al. [12]Not doneNot doneNot doneNot doneNot doneNot doneCytokeratin+

15Terada [13]Not done+Not doneKi-67 labeling = 15%; +cytokeratins; +EMA; α-methylacyl CoA racemase; +Ca19-9; MUC1

16Terada [13]Not doneNot done+Not doneKi-67 labeling = 30%; +cytokeratins; +EMA, +p63, +p53, +C10, +CEA, +MUC1

17De Berardinis et al. [14]Not doneNot doneStrongly+Not doneKi-67 +high expression

18, 19, 20, 21, 22, 23, 24Cardillo et al. [15] (7 cases)Not doneNot doneNot doneNot done

25Dundar et al. [16]Not done +40% +40%Not doneKi-67 20%; 34βE12; −PSA; −AE1

26Dundar et al. [16]Not done+50%+40%Ki-67 15%; +34βE12; −PSA; −AE1

27Badoual et al. [17]Details not availableDetails not available Details not available Details not available Details not available Details not available Details not available Details not available Details not available Details not available Details not available Details not available

28Badoual et al. [17]Details not available Details not availableDetails not availableDetails not available Details not available Details not available Details not available Details not available Details not available Details not available Details not available Details not available

29Krishnamoorthy et al. [18]Details not available Details not available Details not available Details not available Details not available Details not available Details not available Details not available Details not available Details not available Details not available Irregular nests of tubules in lamina propria

30.Ozdemir et al. [19]Not doneNot doneNot doneNot doneNot doneDetails not available to author

31 Holmäng and Johansson [20]Details not available to authorDeatials not available to author Deatials not available to author Deatials not available to author Deatials not available to author Deatials not available to author Deatials not available to author Deatials not available to author Deatials not available to author Deatials not available to author Deatials not available to author

32Ooi et al. [21]Details not available to authorDetails not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author

33 to 86Linder et al. [22]52 patientsDetails not availabeDetails not availabe Details not availabe Details not availabe Details not availabe Details not availabe Details not availabe Details not availabe Details not availabe Details not availabe

87Tripodi et al. [23]Not doneNot doneNot done+P63

88Cerda et al. [24]Not doneNot doneNot doneNot doneNot doneNot doneNot doneNot done+CK7,+CK20,
+34βE12, +P63

89Cerda et al. [24]Not doneNot doneNot doneNot doneNot doneNot doneNot doneNot doneNot doneNot done+CK7,+CK20, +34βE12, +P63

90 Yildiz et al. [25]Details unavailableDetails unavailable Details unavailable Details unavailableDetails unavailableDetails unavailable

91 Pusztaszeri et al. [26] Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author

92Lau [27]Details not available to authorDetails not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author

93Stern [1] Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author

94–96Talbert and Young [3]Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author

97–100Murphy and Deana [4]Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to authorDetails not available to author

101–130Wasco et al. [8]CK7+ (93%); CK20+ (68%); P63+ (92%); CK903+ (92%)

131–134Young and Oliva [9]Details not available to authorDetails not available to author Details not available to author Details not available to author Details not available to author Details not available to authorDetails not available to author Details not available to author Details not available to author Details not available to author Details not available to author

135–150Drew et al. [10]Details not available to authorDetails not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author

151 and 152Xiao et al. [28]High +p53Both Strongly+ for 63;
and High Ki-67 indices
Case 1
+CK 903;
+CK7
+CK20;
−PSA; −prostatic acid phosphatase;
Strongly +p63;
+p53 40% to 50%;
+Ki-6730 to
Case 2
+CK903;
+CK7;
−PSA;
−prostatic acid phosphatase;
−S100;
−chromogranin;
+p63 30 to 40%;
Focally +p53;
Focally +Ki-67

153Huang et al. [29]+CK7;
+CK20;
+thrombomodulin;
+34βE12

154–164Volmar et al. [30]8.8%+p53 4.2%;
+P27 4.7%;

165–174 Holmäng and Johansson [20] 10 casesDetails not availableDetails not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author

175–177Liedberg et al. [31]Details not availableDetails not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author

178–200Cox and Epstein [32]Details not availableDetails not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author Details not available to author