Table 3: Some of the reported cases of lymphoma of the urinary bladder mainly primary with other cases of paraurethral lymphoma, their management and outcome.

References of cases Treatment typesFollow-up durationComplete remissionPartial remission No response Total sex/age histology

Raderer et al. [11]RCHOP or RCNOP
regime
19 months mean
Range 10–45
20 (77%)6 (23%) 0 26 patients with MALT lymphoma of bladder

Terasaki et al. [12]Radiotherapy Gy 26 and Rituximab chemotherapy after remission 14 months 1 patient 1 female aged 64 years with MALT lymphoma of bladder

Takahara et al. [13]TURBT and Radiotherapy 40 Gy in 20 fractions3 monthly intervals to, duration is not available to author1 patient1 female aged 85 years with extranodal marginal zone B-cell lymphoma

Kakuta et al. [14]Rituximab in combination with CHOPP chemotherapy after transurethral biopsyDuration is not available to author1 patient1 female aged 84 years with extranodal marginal zone B-cell lymphoma of bladder

Siegel and Napoli [15]Extensive resectionDuration is not statedAlive, but outcome with regard to response is not available to authorAlive, but outcome with regard to response is not available to author 1 elderly female with B-cell lymphoma of dome of bladder with signet ring cell component

Hayashi et al. [16]3 courses of R CHOPP chemotherapyDuration is not available to author1 patient1 female age not available to author with DCBCL (primary diffuse large B-cell lymphoma of urinary bladder)

Abraham et al. [17]Resectional biopsy and non-Hodgkin’s lymphoma therapyDuration is not stated11 female aged 72 years with extranodal monocytoid B-cell lymphoma (MBCL) derived from marginal zone lymphocyte

Sundaram and Zhang [18]Resection but details of further management not availableDetails is not available to author 1 female aged 67 years with localized Epstein-Barr virus (EBV) positive B-cell lymphoproliferative disorder (LPD)/polymorphous B-cell lymphoma of the bladder

Oh and Zang [19]Transurethral resection biopsy and two cycles of systemic cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOPP) chemotherapy Duration is not stated 1 patient with simultaneous restoration of urinary function1 male aged 35 years with diffuse large B-cell lymphoma (non-Hodgkin’s lymphoma)

Wang et al. [20]TURBT and four cycles of CHOPP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy 12 months1 with good response and remained in clinical remission for 12 months after treatment1 male aged 45 years with T-cell lymphoma of urinary bladder

Mourad et al. [21]Transurethral resection biopsy of lesion and
CHOPP chemotherapy and he received cyclophosphamide, doxorubicin, vincristine, and prednisone
Duration not available to author: appeared case was reported earlier without details of long-term follow-upResponse not available1 male aged 52 years who had shistosomiasis and found to have T-cell lymphoma of urinary bladder which Mourad et al. [21] felt was induced by shistosomiasis

Ando et al. [22]Transurethral resection of bladder tumour only3 years11 female aged 77 years with primary low-grade B-cell lymphoma of the MALT type

Simpson et al. [23]Details not available to authorDetails are not available to authorDetails not available to author1 female with T-cell primary lymphoma of bladder and urethra

Mearini et al. [24]Transurethral resection of bladder tumour (Burkitt’s lymphoma) plus subsequent antiretroviral treatment with stavudine (40 mg twice daily), lamivudine (150 mg twice daily), and nelfinavir (750 mg 3 times daily), as well as antitumour polychemotherapy (4 cycles of cyclophosphamide, vincristine, doxorubicin, and dexamethasone, alternated with 4 cycles of methotrexate and cytarabine) 8 months of followupComplete resolution and biopsy of small mucosal lesion at site of previous tumour 8 months later only showed fibrous tissue on immunohistochemical and histological examination27-year-old man with Burkitt’s lymphoma

Tsiriopoulos et al. [25]Cystectomy and ileal conduit after failure of conservative treatment for presumed interstitial cystitisDetails are not available to authorDetails are not available to authorDetails are not available to authorDetails are not available to author75-year-old patient with past history of chronic lymphatic leukaemia histology of bladder showed primary splenic marginal zone lymphoma simulating interstitial cystitis

Downs et al. [26]Details are not available to author Details are not available to author Details are not available to author Details are not available to author Details are not available to author They concluded that primary lymphoma of the bladder has a good prognosis and responds to a variety of therapeutic modalities

Simpson et al. [27] 3 cases7 years.
39 months.
Details are not available to author
Alive and free of tumour.
Died after 39 months.
Details are not available to author
A 70-year-old man with low grade type 
A 67-year-old woman with intermediate-grade type 
76-year-old woman with lymphoma in the urethra

Isaacson and Wright [28]2 cases, details are not available to author Details are not available to author Details are not available to author Details are not available to author Details are not available to author Details are not available to author

Ohsawa et al. [10] 3 cases, details are not available to author Details are not available to author Details are not available to author Details are not available to author Details are not available to author Details are not available to author

Sönmezer et al. [9]Transurethral biopsy, partial cystectomy, total hysterectomy, bilateral oophorectomy, and four courses of CHOP regimen (cyclophosphamide, vincristine, doxorubicin, and prednisolone)6 yearsAlive and well with no local recurrence of distant metastasis1 female aged 50 years with high-grade B-cell lymphoma

Kuhara et al. [8]Details of duration of followup are not available to authorOutcome is not available to authorOutcome is not available to author Diffuse B-cell lymphoma of medium-sized cell

Sufrin et al. [7]13% of 599 patients with malignant lymphoma had secondary bladder involvement and were treated with local radiotherapy 1952 to 1972Good response13% of 599 patients with secondary bladder lymphoma (details of the various types are not available to author)

Cohen et al. [6] Details of case are not available to authorDetails of case are not available to author Details of case are not available to author Details of case are not available to author Details of case are not available to author 1 case of primary B-cell lymphoma of bladder

Zukerberg et al. [5] 5 cases (diagnosis of malignant lymphoma was excluded in 1 leaving 4 as lymphoma of T-cell type
Of 2 muscle invasive tumours,
2 cases were too recent to have followup
4
Too recent for followup
1 alive with no tumour after 4 years following radiotherapy. and chemotherapy.
Details are not available to author

Al-Maghrabi et al. [4] Radiotherapy (35 Gy)13 years,
5 years,
3 years,
2 years, 
respectively
Alive no recurrence.
Alive no recurrence.
Alive no recurrence.
Alive with no disease
64-year-old female,stage IAE
69-year-old female, low-grade MALT lymphoma, stage IAE
72-year-old female, low-grade lymphoma of MALT type-stage IAE
62-years-old male, B-cell malignant lymphoma of MALT type-stage IAE

Mantzarides et al. [29]Details of treatment are not available to authorFurther details are not available to authorFurther details are not available to authorFurther details are not available to author Further details are not available to author 82-year-old female with primary diffuse large B-cell lymphoma of the bladder wall

Evans and Moore [30]Transurethral biopsy of bladder tumour and she received a course of R-CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab) chemotherapy 4 monthsCT scan showed regression of lesion and symptomatic improvement64-year-old female with histologically proven diffuse large B-Cell non-Hodgkin’s lymphoma (primary)

Arda et al. [31]Open biopsy; she refused surgical operation and was referred to oncologist for chemotherapyFurther details are not available to author Further details are not available to author Further details are not available to author Further details are not available to author 54-year-old female had open biopsy proven to be malignant non-Hodgkin’s lymphoma

Aceñero, et al. [32]Details are not available to authorDetails are not available to authorDetails are not available to authorDetails are not available to authorDetails are not available to author3 cases of primary malignant lymphoma of urinary bladder (2 of high grade) of MALT type

Jacobs and Symington [33] Cystectomy3 yearsAlive and well with no recurrence of locally or distant metastasis61-year-old woman with primary lymphoma of urinary bladder

Diaz-Peromingo et al. [34]
TUR biopsies and CNOP (cyclophosphamide, mitoxantrone, vincristine, and prednisolone) and monoclonal antibodies anti-CD20Short period of follow-up case reported shortly after initial treatmentGood initial response79-year-old man tumour B-cell lymphoma (non-Hodgkin’s) which was initially thought to be primary; however, PER scan confirmed that it was a secondary bladder lymphoma

Rijo et al. [35]Open per vaginal partial excision of paraurerethal lesion. extending to the trigone of the bladder (this was a paraurethal lesion not a bladder lesion).
Six cycles of immunochemotherapy: anti-CD20 (Rituximab) combined with chemotherapy (high doses of methotrexate and cytarabine with conventional cystostatics and prophylactic administration of G-CSF after chemotherapy cycles).
After the completion of the third cycle of treatment, the patient achieved near-complete remission as well as a nearly complete regression of the paraurethral tumour and the lesion of the 5th lumbar vertebra. Haematological grade 2 toxicity and gastrointestinal grade 1 toxicity were reported
9 months11 female aged 27 years

Hatano et al. [36]Transurethral resection of bladder tumour and left total nephroureterectomy; histology adenocarcinoma G2pT2 in renal pelvis and MALT-type lymphoma of bladder; radiotherapy 36 Gy to bladder14 monthsAlive with no evidence of recurrence84-year-old with MALT-type lymphoma of bladder and adenocarcinoma of left renal pelvis