Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation
Table 3
Resting and maximal cardiorespiratory values and hemodynamic and pulse wave analysis parameters for the short- and longer-term androgen deprivation groups.
Variable
<3 months Mean ± SD
≥3 months Mean ± SD
Mean difference (95% CI)
value
(L/min−1)
2.3 ± 1.0
1.9 ± 0.6
0.4 (0.1, 0.7)
0.035
(mL/kg/min−1)
26.1 ± 6.0
23.2 ± 5.8
2.9 (0.5, 5.3)
0.020
(METS)
7.5 ± 1.7
6.6 ± 1.6
0.9 (0.1, 1.5)
0.020
Test duration (mins)
8.5 ± 2.8
7.6 ± 2.6
0.9 (−0.1, 2.1)
0.080
Resting metabolic rate (kcal/24 hr)
1795 ± 256
1647 ± 236
147 (46, 249)
0.005
Relative total body mass Resting metabolic rate (kcal/kg/24 hr)
21.5 ± 3.0
20.0 ± 2.6
1.5 (0.3, 2.7)
0.017
Relative lean body mass Resting metabolic rate (kcal/lean kg/24 hr)
30.5 ± 3.2
29.2 ± 4.1
1.3 (−0.2, 2.9)
0.079
Peripheral SBP (mmHg)
150.9 ± 19.9
149.0 ± 19.4
1.9 (−5.8, 9.6)
0.624
Peripheral DBP (mmHg)
85.6 ± 12.1
84.5 ± 10.4
1.1 (−3.4, 5.6)
0.626
Peripheral MAP (mmHg)
108.4 ± 15.0
107.2 ± 12.8
1.2 (−4.3, 6.7)
0.669
Central SBP (mmHg)
139.1 ± 21.1
138.7 ± 20.2
0.4 (−7.7, 8.5)
0.922
Central DBP (mmHg)
86.8 ± 12.3
85.5 ± 10.6
1.3 (−3.2, 5.8)
0.571
Central MAP (mmHg)
108.9 ± 16.1
107.2 ± 12.8
1.7 (−4.1, 7.5)
0.557
Peripheral augmentation index (AIx, %)
83.5 ± 13.0
86.5 ± 13.9
−3.0 (−8.3, 2.3)
0.261
Central augmentation pressure (mmHg)
15.4 ± 8.2
16.7 ± 9.6
−1.3 (4.8, 2.1)
0.445
Augmentation load (mmHg)
14.3 ± 5.0
14.6 ± 4.9
−0.3 (−2.3, 1.6)
0.732
Central augmentation index (AIx, %)
140.4 ± 17.8
144.4 ± 19.6
−4.0 (−11.3, 3.3)
0.281
Pulse wave velocity (m/s)
10.0 ± 1.4
10.0 ± 1.8
0.0 (−0.6, 0.7)
0.983
: maximal oxygen uptake; METS: metabolic equivalents; SBP: systolic blood pressure; DBP: diastolic blood pressure; MAP: mean arterial pressure; AIx: augmentation index. refers to a significant difference between <3 months and ≥3 months.
