Review Article
Toxicities Associated with Cisplatin-Based Chemotherapy and Radiotherapy in Long-Term Testicular Cancer Survivors
Table 1
Prevalence of cardiovascular disease risk factors in chemotherapy-treated patients in select studies since 2000.
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Adapted with permission from Feldman et al. [9] (Table 2). AHA: American Heart Association; BMI: body mass index; DBP: diastolic blood pressure; DM: diabetes mellitus; NHLBI: National Heart, Lung, and Blood Institute; NHANES: National Health and Nutrition Examination Survey; TC: testicular cancer; HTN: hypertension; LDL: low-density lipoprotein; NA: not available; NCEP: National Cholesterol Education Program; SBP: systolic blood pressure; TC: total cholesterol. (a) N varies slightly for individual factors due to missing data in papers for some variables. (b) Definitions of individual factors vary by study. Comparisons of chemotherapy group to controls significant unless otherwise stated; percentages vary slightly due to missing data for individual factors. (c) Cholesterol and fasting glucose values in definitions were converted from mml/L to mg/dL, where necessary for uniformity. (d) Not significant. (e) Significant versus healthy population controls but not versus surgery patients. (f) Includes both orchiectomy and primary retroperitoneal lymph node dissection patients. (g) A healthy population control group was also included in this study, but prevalence rates of cardiovascular risk factors were not reported for this control group, and therefore these data are not included in the table. (h) Significant only for patients who received >850 mg of cisplatin. (i) Significant versus surgery patients but not versus healthy controls. (j) 20 patients received carboplatin and 174 patients received combination chemotherapy. (k) Significant for patients who received combination chemotherapy compared to healthy population. (l) Significance versus controls not tested. |