Advanced Prostate Cancer: Local and Systemic Options
1Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, 93053 Regensburg, Germany
2Department of Urology, Klinikum Großhadern, Ludwig-Maximilian University Munich, 81377 Munich, Germany
3Department of Radiation Oncology, Regensburg University Medical Center, 93053 Regensburg , Germany
4Department of Urology, University of California at Davis, Sacramento, CA 95817, USA
Advanced Prostate Cancer: Local and Systemic Options
Description
Recently the larger and public discussions on prostate cancer seem to have focussed on two aspects: firstly, the usefulness of PSA screening more often than not detecting insignificant disease and, secondly, therapeutical strategies for low-risk cancer aiming at advantageous functional outcome ranging from robotic surgery and nonsurgical interventions to active surveillance.
However, the current and partly fierce debates should not mask the fact that an abundance of men are stricken by the sequels of advanced prostate cancer and finally succumb to this malignancy. While current oncological strategies have achieved long-term survival in many cases, patients yet often suffer from local complications, and as clinicians worldwide are faced with respective problems, we need to find answers to pressing questions.
Can we reliably assess prognosis in metastatic disease? Which is the best approach to hormonal ablation and when should we add or shift to chemotherapy? Would novel drug classes make sense? What could molecular biology teach us? And last but not least, how can we optimize local measurements in metastatic patients and is a radical prostatectomy even in metastatic settings and local treatment of filiae feasible for selected patients?
We sincerely invite investigators to contribute to original research and review papers for this special issue that certainly will stimulate the endeavour to find solutions to this pressing topic. Potential topics include, but are not limited to:
- Molecular mechanisms of disadvantageous tumour biology
- Developments in the assessment of advanced tumour stages
- Advances in prognostic models for locally advanced and metastatic stages
- Current concepts of hormonal ablation and chemotherapy
- Multimodal treatment approaches using novel drug classes
- Role of transurethral and radical surgery
- Recent approaches to radiation of primary and distant tumour sites
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