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Autism Research and Treatment
Volume 2011 (2011), Article ID 545901, 19 pages
The Broader Autism Phenotype and Its Implications on the Etiology and Treatment of Autism Spectrum Disorders
1Department of Psychology, University of Washington, Seattle, WA 98195, USA
2Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
Received 11 August 2010; Revised 13 March 2011; Accepted 9 May 2011
Academic Editor: Connie Kasari
Copyright © 2011 Jennifer Gerdts and Raphael Bernier. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The presence of autism-related traits has been well documented in undiagnosed family members of individuals with autism spectrum disorder (ASD). The most common finding is mild impairments in social and communication skills that are similar to those shown by individuals with autism, but exhibited to a lesser degree. Termed the broader autism phenotype (BAP), these traits suggest a genetic liability for autism-related traits in families. Genetic influence in autism is strong, with identical twins showing high concordance for the diagnosis and related traits and approximately 20% of all ASD cases having an identified genetic mechanism. This paper highlights the studies conducted to date regarding the BAP and considers the implications of these findings for the etiology and treatment of ASD.
1. Autism Spectrum Disorders
Autism Spectrum Disorder (ASD), including Autistic Disorder, Asperger’s Disorder, and Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS), is both genetically and phenotypically heterogeneous. ASD is diagnosed in males four times more often than in females, approximately 65% of individuals with ASD have cooccurring intellectual disability , language abilities range from nonverbal to verbally fluent , and regression between one and two years of age (mean age 17 months) is reported in approximately one-third of all cases .
Genetic heterogeneity is noted in ASD as well. Genetic influence in autism is strong, with concordance rates in twins ranging from 60–96% in monozygotic (MZ) twins compared to 0−23% in dizygotic (DZ) twins depending upon the sample and diagnostic boundaries [4–6]. Approximately 10–20% of ASD cases likely have a genetic cause through an identifiable genetic syndrome, observable genetic mutation, or de novo copy number variant (CNV; ). Nearly 20 mutations relevant in ASD have been identified to date, with more likely on the horizon . However, no single genetic mutation explains a large number of ASD cases and the presence of any one of the risk CNVs does not necessarily prescribe a diagnosis.
2. Broader Autism Phenotype
Psychological characteristics of relatives of children with ASD were first noted in Leo Kanner’s 1943 paper in which he noted “For the most part, the parents, grandparents, and collaterals are persons strongly preoccupied with abstractions of a scientific, literary, or artistic nature, and limited in genuine interest in people [44, page 250].” Empirical studies following this line of research initially focused on rates of cognitive disorders, such as intellectual disability, learning disabilities, and language disorders, in family members without a diagnosis of ASD. Elevated rates of such disorders were noted in siblings of individuals with ASD [45, 46]. However, later reports suggested that these cognitive deficits may instead have been markers of intellectual disability rather than autism per se as they were generally present in relatives of individuals with ASD and intellectual disability, but not in relatives of children with ASD with normal intelligence . Since then, the majority of studies have failed to document increased rates of cognitive dysfunction in relatives, regardless of the intelligence level of the affected child [11, 17, 48].
Studies do consistently describe a milder phenotype in relatives of individuals with ASD that is qualitatively similar to the defining features within the three domains of ASD: social, communication, and restricted interests and behaviors (e.g., [10, 12, 16, 22]). These subclinical differences in social skills and traits, communication abilities, and personality traits are generally considered to constitute the broader autism phenotype (BAP). Studies have generally compared parents of children with ASD (hereafter termed ASD parents) and unaffected siblings of individuals with ASD (hereafter termed ASD siblings) to family members of control subjects. Subsequent studies have identified variations in social cognition abilities (e.g., ), neurocognitive functioning (e.g., ), and biological dimensions (e.g., ) as well that perhaps relate to or explain the clinical presentation of the BAP. Early markers of the BAP are currently under investigation in infancy (e.g., [52–54]).
The purpose of this paper is to provide a comprehensive review of the available literature on the BAP in ASD parents and siblings. We begin by reviewing studies examining social abilities, communication skills, and personality traits. We then summarize measures available to assess the BAP in ASD parents and siblings. In subsequent sections, we explore neurocognitive functioning in relatives as well as studies conducted on biological features, such as head circumference and neural functioning, of ASD parents and siblings. Additionally, we summarize findings on the relationship between characteristics of individuals with ASD, family structure, and the BAP in ASD parents and siblings. Finally, we discuss the clinical and etiological implications of the BAP.
The BAP itself is not a diagnostic entity. In general, difficulties and differences evidenced in ASD parents and siblings are much milder than those of their child/sibling with ASD and do not fall in the clinically significant range. ASD parents and siblings may demonstrate more BAP features than controls, but the traits, by definition, do not cause enough functional impairment to justify a clinical diagnosis. Therefore, while we summarize a number of statistically significant differences between family members and controls within this line of investigation, we do not suggest that that these features generally warrant clinical concern.
Like the diagnosis of ASD, BAP traits tend to aggregate more often in male relatives than female relatives [12, 16, 19, 30, 31], although this finding is not universal (e.g., [10, 15]). Informant report of social, communication, and repetitive behaviors in grandparents, aunt/uncles, and first cousins of individuals with ASD have suggested that these relatives exhibit similar, but less pronounced differences [16, 19, 55]. Importantly, most studies find that at least half of relatives do not have quantifiable impairments (e.g., [8, 10, 15, 27]), implying that differences may be present in only a subset of family members.
2.1. Social Abilities, Communication Skills, and Personality Traits
The most consistent evidence for the BAP emerged from studies directly assessing social communicative skills, personality traits, and histories in relatives. Early criticisms of such studies centered on the use of relatives of typically developing children as control groups. Critics noted that the differences found in relatives of children with ASD might have resulted from the environmental effects of living with and/or raising a child with a severe disability rather than genetic similarity. Therefore, many researchers changed the nature of their control groups to include family members of children with a developmental disability, often Down syndrome (DS), in order to control for the effects of having a child with disability as a family member. While including families of children with a nonfamilial disability such as DS addresses the environmental influences of living with a child with a significant disability, some researchers have preferred to include a second control group to account for other familial aspects of ASD. For example, developmental language disorders often have a strong genetic component and are included in some studies to control for genetic influences in ASD (e.g., ).
Social traits, such as decreased interest in reciprocal social interactions and a focus on special interests as a conversational topic, identified using clinical interviews have been noted more often in ASD parents and siblings compared to parents and siblings in control groups, [8, 12, 16]. Personality types relating to decreased interest in social interactions (“aloof”), showing a restricted range of affective expression (“undemonstrative”), and using behavior that is interpreted to be off-putting (“untactful”) are also more often more common in ASD parents and siblings compared to controls [13, 15, 18]. Other personality traits (“rigid”) relating to decreased flexibility and difficulty adjusting to changes (e.g., altered routines) have also been reported in ASD parents compared to controls [15, 33]. Self-report generally corroborates findings from clinical evaluations and interviews [20, 21].
ASD parents and siblings also consistently show differences compared to control groups in social communication skills using clinical interview [10, 15, 23, 57]. Self-report of pragmatic language, the social use of language in the context of verbal or nonverbal exchanges, in parents supports these findings . Table 1 provides an overview of the chief findings from BAP studies conducted to date examining social abilities, communication skills, and ASD-related personality traits in ASD parents and siblings. Table 2 outlines measures designed specifically to assess these traits.
2.2. BAP in Infancy
The majority of BAP studies have focused on parents and school age siblings of children with ASD. However, prospective studies following infant siblings of older children with ASD are ongoing to determine the nature and timing of the BAP in early childhood. Although the precise presentation of the BAP in infancy and its relation to later development remains unclear, several studies have documented social and communication differences in infant/toddler-aged younger siblings of children with ASD who do not go on to be diagnosed ASD (hereafter termed non-ASD sibs) (e.g., [58–60]). A study examining the BAP in toddler-aged non-ASD sibs reported decreased social communication, cognitive, adaptive, and language abilities via both observational and parent report measures . The use of pointing, directed facial expressions, and the quality of social overtures discriminated non-ASD sibs from control infant siblings in a different sample at 18 months of age . Hutman and colleagues  reported that while response to name and showing appropriate response to distress was impaired in infant siblings who were diagnosed with ASD, these variables did not distinguish non-ASD sibs from typical infants. This suggests that response to name and response to distress are not early signs of the BAP, but may be part of the early presentation of ASD . Gamliel et al.  reported that some non-ASD sibs with cognitive delays at 14 and 24 months were no longer delayed cognitively in preschool years. However, expressive and language delays remained in a portion of these non-ASD sibs . The language-related delays continued into school age years and emerged as language-related learning and academic difficulties in 40% of ASD siblings versus 16% of control children, as reported in a follow-up study . Therefore, there may be variability in the developmental trajectory of non-ASD sibs, with delays from some early challenges resolving by later childhood and others continuing into school age years.
Christensen and colleagues reported fewer functional play skills and increased repetitive nonfunctional play in non-ASD sibs compared to controls . Increased repetitive interests and atypical sensory behaviors were also observed in non-ASD sibs versus typical infants in a separate longitudinal study . A number of studies on infant siblings have reported decreased visual attention to social stimuli, increased attention to nonsocial stimuli, and difficulty disengaging from one stimuli to another [59, 64, 65]. However, diagnostic outcomes have not yet been reported in these studies, so it is unclear if these traits are early markers of ASD itself or an early manifestation of the BAP.
Overall, ASD-related traits may be present at a very early age in relatives of individuals with ASD; however, followup of these infants and toddlers are necessary as certain findings have been inconsistent across studies and some of these differences have resolved later in life. See Rogers  and Zwaigenbaum et al.  for more comprehensive reviews of this emerging area of interest.
3. Depression and Anxiety
Piven and colleagues  first reported increased rates of depression and anxiety in adult siblings of individuals with ASD based on direct assessments. Additional studies corroborated these early reports, with major depression, obsessive compulsive disorder, and social phobia being the most commonly observed diagnoses in first degree relatives [68–71]. Depression and anxiety diagnoses seem to be more prevalent in female relatives, particularly mothers, compared to male relatives . It is reasonable to assume that having a child with autism significantly impacts mood and anxiety levels. However, studies have indicated that affective episodes in relatives had an onset prior to the birth of their child(ren) with ASD and suggest that the stress of raising a child with autism did not cause the psychopathology [68, 70]. Additionally, mood and anxiety symptoms are largely unrelated to the presence of BAP traits in an individual [68, 70], although a more recent study did report a relationship between depressive symptomotology and BAP traits via self-report on the AQ .
4.1. Intelligence/General Cognitive Abilities
Intelligence and general cognitive abilities in individuals with ASD can range from significantly below average in the intellectual disability range to above average in the intellectually gifted range. Given these variable intelligence levels, researchers have examined intellectual functioning in relatives of children with ASD. Although early reports suggested below average intellectual functioning and cognitive disabilities in ASD siblings [45, 46], many subsequent studies have failed to support these initial findings [11, 17, 48]. Full scale IQ in ASD parents and siblings has since been found to be in the average to high average range in most research studies (e.g., [11, 42, 48, 73–75]).
Another often-reported finding in individuals with ASD is a pattern of significant variability in cognitive abilities, such as enhanced visual spatial and nonverbal reasoning skills compared to knowledge of vocabulary and comprehension of language [76, 77]. Studies of ASD parents and siblings have similarly documented increased variability in general cognitive abilities as measured by intelligence tests compared to control groups suggesting a possible association of cognitive variability to the BAP [17, 56, 73, 78, 79].
4.2. Central Coherence
There are several cognitive theories that attempt to explain the triad of impairments in ASD. One such theory involves a cognitive process called central coherence. Central coherence is a model of cognitive processing style ranging from a tendency to focus on smaller details with a weakness in seeing more global perspectives (local processing bias) to a propensity for seeing the gestalt while sacrificing details (global processing bias). Weak central coherence results in an overfocus on the parts rather than the whole while strong central coherence involves a good understanding of the larger picture, but less attention to details. The block design subtest included in many intelligence tests has been considered a proxy for central coherence since breaking down the picture to be replicated into its parts is the most efficient strategy for completing the task. Individuals with ASD have been purported by some groups to have weak central coherence [80, 81] while others have reported intact central coherence in children with ASD [82–84]. Thus, the validity of the central coherence theory in ASD remains unclear.
In a two-part exploration of central coherence in relatives, Briskman and colleagues [20, 85] compared central coherence among parents and siblings of individuals in three groups: no developmental abnormality, dyslexia, and ASD. Fathers of children with ASD demonstrated differential performance suggestive of weak central coherence on all measures . There were no differences between mothers of children with ASD and controls on any of the tasks, suggesting sex differences in central coherence in relatives. On self-report assessing the social and nonsocial (e.g., special interests, sensory sensitivities, and preference for routines) aspects of the BAP, those parents (particularly fathers) with greater nonsocial scores tended to have weaker central coherence . A separate research group has also documented weak central coherence compared to controls .
However, weak central coherence was reported to be absent in ASD siblings, suggesting no apparent differences in central coherence in ASD siblings, male or female . A number of additional studies have reported intact central coherence and failed to document differences between ASD relatives and controls in tasks purported to tap into central coherence, such as block design [28, 29, 78, 86]. Therefore, like the debate about the validity of the central coherence theory in individuals with ASD, the relation of weak central coherence to the BAP remains to be determined.
4.3. Executive Functioning
Another cognitive theory of the underlying processing mechanism in ASD involves a primary deficit in executive functioning (EF). EF encompasses abilities that underlie goal-directed behavior, including working memory, inhibition, cognitive flexibility, and planning. Individuals with ASD often have difficulty with EF tasks [87, 88]. However, there is substantial debate over the exact nature of EF challenges in ASD, and differences noted may be measure specific.
Differences in EF are documented in ASD parents and siblings as well compared to controls. Compared to parents of children with learning disabilities and typically developing children, ASD parents, particularly fathers, showed challenges on computerized tasks of four components of EF: attentional flexibility, planning, spatial working memory, and spatial short-term memory . Attentional flexibility was particularly difficult with half of ASD parents showing an impaired ability to shift problem-solving strategies when necessary compared to a small percentage of control parents. In another study, parents within multiple-incidence ASD families demonstrated poorer performance compared to parents of children with DS on the Tower of Hanoi task, a measure of planning .
Studies of ASD siblings have showed the same general trend. Hughes and colleagues  found that a greater percentage of ASD siblings demonstrated increased difficulty with attentional flexibility and more advanced stages of planning on a computerized EF task compared to siblings of children with severe to moderate developmental delays and neurotypical children. In another study, there was a significant difference between ASD siblings’ performance on the Tower of Hanoi task compared to siblings of children with various other learning disabilities . Precursors to executive functioning abilities have recently been examined in infancy. Latency in disengaging from one stimulus to attend to another has been reported in a subset of infant siblings of children with ASD compared to control infants .
Wong and colleagues  suggest that poor planning may reflect an EF challenge in generativity in ASD, meaning difficulty generating more than one strategy to solve a problem (also called fluency). In their study comparing ASD parents and siblings to relatives of children with mild intellectual disabilities, they found differences in several measures of verbal and nonverbal generativity/fluency between index family members and controls .
Working memory challenges that are often present in individuals with ASD are also present to a lesser degree in ASD parents. One study reported that ASD parents scored significantly lower on a verbal working memory task compared to parents of typically developing children . ASD parents made more errors in a delayed oculomotor response task assessing spatial working memory via tracking of saccades (or fast movements of the eye) compared to control adults . However, many of these same EF studies have not documented differences in every measure in their battery [11, 50, 74, 92, 94] and some have found no differences on any measure of EF .
4.4. Social Cognition
An additional theory purporting to explain the underlying social and communication difficulties observed in ASD involves a primary deficit in social cognition: specifically a construct called theory of mind (ToM). ToM involves the ability to understand other’s emotions, motivations, and intent. It allows individuals to take another person’s perspective and intuit his or her mental state.
Mild ToM challenges in using facial cues and other features to determine mental states have been noted in relatives of individuals with ASD. For instance, Baron-Cohen and Hammer  found that ASD parents, particularly fathers, were slightly less able to determine the thoughts and feelings of people based solely on photographs of their eyes (Reading the Mind from the Eyes test) compared to adult controls. Another study using this task found a trend toward differences in ASD parents compared to parents of typically developing children ; a similar pattern of results has been noted in ASD siblings compared to control children using the same measure . Significant differences in an advanced ToM task were detected in ASD parents’ ability to reason about emotions in order to correct inconsistencies in emotional expressions. Additional studies have reported similar differences using advanced ToM experimental tasks  and self-report of emotion processing abilities, particularly emotion identification , in ASD parents compared to control parents. However, several studies have reported no difficulties in ToM tasks in ASD siblings compared to siblings of individuals with other developmental disabilities [11, 90, 97].
The relationship between social and communication skills and ToM abilities in ASD parents has also been examined. Findings from two recent studies suggest that impairments on specific aspects of social cognition may only be relevant for subgroups of ASD parents with social features of the BAP: namely, those with “aloof” personality styles involving social dispositions relating to preference for alone time and infrequent use of social chat during social exchanges [25, 29]. ASD parents without this personality style did not demonstrate difficulties on ToM tasks.
5. Language Abilities
5.1. Phonological Processing and Reading Abilities
Phonological processing is the manner by which written and spoken words are processed and can be crucial for strong reading and writing abilities. These skills are heritable (e.g., [98, 99]) and some children with ASD show marked impairments in measures of phonological processing . Evidence suggests that only children with ASD who have a language impairment (and not those without a language impairment) have challenges in phonological processing and reading-related skills, similar to children with a Specific Language Impairment (SLI) without ASD [100–103]. Therefore, it is possible that reading-related challenges and phonological processing skills are not specific to the ASD phenotype per se, but related to overall language challenges.
Compared to age- and sex-matched adults, ASD parents scored lower on the nonword repetition task (a measure of phonological processing; ). This was a particular challenge for nonwords of three syllables or more, suggesting that phonological short-term memory, rather than perception of sounds or sound production, may be a specific area of interest for future study. A similar report of increased difficulties in reading of nonwords longer than three syllables in a much larger sample was noted in ASD parents (particularly those with a history of language-related challenges) compared to DS parents . In a study of multiplex families, ASD parents demonstrated weaker performance on some reading measures (e.g., passage comprehension and rapid automatized naming) compared to parents of individuals with DS . Rapid automatized naming skills in ASD parents and their high-functioning children were related, with both groups showing longer latencies than DS parents . Rapid automatized naming skills in ASD parents (particularly fathers) related to retrospective reports of early language delay and were associated with a socially reticent personality style.
However, many studies have failed to report difficulties in phonological processing and reading abilities in relatives. For example, Bishop and colleagues  found no differences between parents and siblings of children with ASD versus those of typically developing children of a variety of different IQ levels on measures of phonological processing (nonword repetition and reading of nonword passages). Additionally, no differences between ASD siblings and control siblings were noted in other studies examining word fluency, rapid automatized naming, and pragmatic language [56, 97]. An additional study compared language, reading, and phonological processing abilities in ASD parents and siblings of children both with and without language impairment to parents and siblings of children with SLI . While parents and siblings of children with ASD who had a language impairment scored lower than relatives of children with ASD who did not have an impairment, neither groups’ scores were in the impaired range. Additionally, SLI relatives scored significantly lower than both groups, suggesting separate genetic etiologies of language impairments in probands within these two disorders . Therefore, research suggests that challenges in reading abilities and phonological processing may be absent in ASD siblings and unclear in ASD parents.
5.2. Structural Language
ASD parents and siblings are more likely than controls to have had an expressive language delay in childhood as well as other language-based learning deficits, such as dyslexia [12, 14, 16, 106]. However, a number of other studies have failed to report difficulties in structural language problems in relatives. Whitehouse et al.  compared ASD parents to parents of children with language and/or literacy impairments and typically developing children found that structural language-related challenges only presented in parents of children with language/literacy impairments, but not those of children with ASD. In ASD siblings, Pilowsky and colleagues  found that ASD siblings and siblings of children with intellectual disability had better developed receptive and expressive language skills and higher verbal IQs than siblings of children with language disorders . Therefore, it is unclear the extent of these reported language difficulties and it is possible that some early language challenges may resolve by later childhood and adulthood.
6. Biological Dimensions
6.1. Head Circumference and Brain Volume
Macrocephaly is a consistent physical finding reported in individuals with ASD. Indeed, many studies have found increased head circumference (HC) in both children and adults with ASD compared to age-based normative measurements [5, 107–110]. Similarly, magnetic resonance imaging (MRI) studies find increased cerebral volume in children with ASD compared to typically developing children and those with other developmental delays [111, 112]. Brain overgrowth appears to represent both greater brain tissue volume and greater lateral ventricle volume .
Despite this well-replicated finding of increased head size and brain volume in ASD, macrocephaly does not appear to define a specific subgroup of clinical features. Some studies have found that increased head size in ASD is advantageous and is related to higher IQ  and better social skills  whereas others have reported negative effects, such as delayed onset of words , more impaired social cognition , and increased stereotyped behaviors . Still other studies have found no direct associations between HC-and ASD-related symptoms . Children later diagnosed with more severe ASD demonstrated a faster and greater rate of brain overgrowth during infancy, compared to children with less severe symptoms .
Less research has been conducted on HC/brain volume among family members of individuals with ASD. The limited research available does suggest that head size is increased in family members. In first-degree relatives, 18.9% of ASD parents and 11.4% of ASD siblings had HC measurements exceeding the 97th percentile . These numbers were significantly elevated compared to normative measurements, but were not different from the comparison group, consisting of family members of individuals with tuberous sclerosis and seizure disorders. In other family samples, HC of ASD parents were skewed toward macrocephaly [110, 115]. The trait appears to be familial as 35–45% of affected children with macrocephaly had a macrocephalic parent [110, 115]. However, in another sample, brain volume of ASD parents was not different from controls .
Two studies have examined the relation between HC and BAP traits in ASD relatives. Elder and colleagues  reported that young siblings of children with ASD with a faster rate of growth in HC in the first year of life followed by slowing of growth in the next year had a greater number of BAP traits. In contrast, Constantino and colleagues  failed to find a relationship between ASD traits as measured by the SRS and rate of head growth in infant male siblings of children with ASD.
6.2. Neural Functioning and Structure
Neural studies using technologies such as electroencephalography (EEG) and functional MRI (fMRI) provide further support for biological differences between ASD parents and siblings and control groups. In a small pilot study, Baron-Cohen and colleagues  compared ASD parents to adult controls using fMRI on a visual search task and an advanced emotion recognition task (both of which differentiate controls from individuals with ASD using the same technology). Findings corroborated an earlier report from the same group of differences in behavioral outcomes on both of these tasks  as well as atypical brain response compared to controls. Additionally, mothers and fathers processed the tasks differently at a neural level, providing further support for sex differences in the presence of the BAP .
Facial processing also appears to be different in ASD parents and siblings. Dawson and colleagues  reported that ASD parents showed a delay in the face-related event related potential (ERP) component, the N170, when looking at faces, although not when looking at objects, suggesting a neural difference in face processing . In a second facial processing study using eye tracking and imaging, ASD siblings spent significantly less time looking at eyes in photographs compared to controls, but spent the same amount of time looking at eyes as their siblings with ASD . The ASD siblings showed greater activation to faces in the right posterior fusiform gyrus but not the left, which was largely accounted for by eye fixation . Emerging evidence for an atypical neural response to direct eye gaze in infant siblings has also been reported .
Total brain and brain structure volume has been explored in ASD parents and ASD siblings. Kates and colleagues  found that monozygotic twin pairs who were concordant or discordant for ASD had similar cerebral gray and white matter volumes. However, only the concordant twin pairs had similar cerebellar gray and white matter volumes. Compared to control subjects, both diagnosed and undiagnosed twins within discordant twin pairs exhibited lower frontal, temporal, and occipital white matter volumes, suggesting that this neural difference is also present in undiagnosed relatives . Compared to controls, ASD siblings show decreased amygdala volume . Conversely, in ASD parents, left hippocampal volume was found to be larger compared to typical adults . ASD parents have also shown increases and decreases in regional gray matter volume using voxel-based morphometry, a finding similar to observed variations in brain structure in individuals with ASD .
7. Moderators of the BAP
7.1. Traits of Affected Children
Various aspects of the BAP appear to be present in relatives across subtypes of individuals with ASD. ASD parents whose children experience a regression in skills demonstrate characteristics of the BAP at the same rates as those whose children do not experience a regression (27.8% versus 32.9%; ). Child gender also does not appear to be related to the degree of expression of the BAP in relatives [12, 55]. Cognitive ability of children with ASD is unrelated to the degree of expression of the BAP in parents [13, 17, 21, 48]. However, Szatmari and colleagues  reported that social and communication impairments were more common in immediate and extended relatives of affected children with IQs above versus below 60.
The severity of ASD symptoms in affected children appears to be related to BAP traits in family members. Pickles and colleagues  found that the severity of symptoms in verbal children with ASD was related to the degree of expression of the BAP in family members, but was unrelated in nonverbal affected children. Similarly, self- and informant-reports of autism-related traits in the typical population indicate that families in which both parents show subthreshold social reciprocity challenges are more likely to have children with scores in the impaired range of social behavior suggestive of an ASD diagnosis . Additionally, while social responsiveness (assessed via the SRS) in parents, probands, and siblings did not predict diagnostic status of infant siblings in a one study, social responsiveness in fathers predicted proband social responsiveness and proband responsiveness predicted sibling responsiveness . Therefore, there is some evidence that the severity of autism-related traits is correlated within some families, particularly in males.
7.2. Family Structure
The number of affected children within a family also relates to BAP traits in family members. A number of studies to date have compared relatives within simplex and multiplex ASD families on measures of the BAP. Szatmari and colleagues  screened nearly 2,000 immediate and extended relatives and found that social impairments, but not communication challenges or presence of restricted behaviors, were more common in multiplex relatives as compared to simplex relatives . Bölte and Poustka  found that simplex ASD parents and siblings demonstrated superior performance in emotion recognition compared to ASD parents and siblings within multiplex families. Virkud and colleagues  found that mean scores on the Social Responsiveness Scales (SRS) in ASD male siblings from simplex families were substantially lower than mean scores in ASD siblings from multiplex families. There was a trend in the same direction on spouse-report SRS for fathers, but not mothers . A more recent study examining relatives within multiplex and simplex ASD families and relatives of typically developing children replicated findings of increased BAP severity in siblings . Siblings within multiplex families had significantly greater SRS scores than siblings within simplex families, with both groups showing greater BAP severity than typical siblings. No differences between multiplex and simplex fathers or mothers were reported .
In the most extensively phenotyped sample to date, Losh and colleagues  found a nearly consistent linear trend across measures of personality traits associated with the BAP, friendship preferences, and pragmatic language between simplex and multiplex ASD parents and DS parents. The multiplex ASD parents had more BAP traits than simplex ASD parents and the simplex ASD parents had more traits than DS parents. Additionally, it was more common in multiplex than simplex ASD families for both parents to show features of the BAP . Schwichtenberg and colleagues  prospectively followed infant siblings of children with ASD and found that infants within multiplex families were more likely (64%) to develop ASD than simplex (9%) and control families (4%).
Overall, these findings lend support to the theory that families containing multiple children with ASD families carry a higher loading for ASD-related traits given that the presence of such traits is more common in this family type than in families containing just one child with ASD. Additionally, a number of genetic studies have found that de novo or sporadic CNVs (a type of genetic mutation) are more common in simplex ASD families as compared to both multiplex ASD families and families without any history of ASD [129–131]. Therefore, it is possible that the types of genetic causes of ASD may vary between single-incidence and multiple-incidence families.
If affected children from simplex families are more likely than those from multiplex families to develop ASD as a result of a de novo genetic event occurring only in that individual, then findings of an increased presence of ASD-related traits in multiplex families may suggest that such family members are more vulnerable to ASD symptoms given shared genetic variance. However, the validity of this phenomenon requires future research attention since few studies have directly tested this hypothesis and findings are not universal [96, 132].
A number of domains have been studied in ASD parents and siblings. Mild differences in social and communication skills related to the core deficits in ASD are present in a subset of relatives and are reported nearly consistently across studies. Therefore, social and communication impairments are likely the most familial of autism-related traits. Variable cognitive abilities, differences in theory of mind and executive functioning skills, increased head circumference, and differences in neural functioning and structure have all been documented in ASD parents and siblings. However, many studies have reported contradictory findings in other areas (e.g., central coherence and phonological processing), making their association with the BAP questionable.
9. Etiological and Clinical Implications
The range of potential symptom profiles that can emerge from the varied deficits in social communication and behavior in ASD results in a complex behavioral presentation. The use of general, overarching diagnostic categories in complex psychiatric disorders such as ASD has often muddied genetic studies with these groups. Therefore, defining quantifiable components of the phenotype that are theoretically more closely tied to genetic vulnerability than a qualitative diagnosis helps to isolate traits for genetic and neurobiological analysis [133–135]. Investigations of component traits in biological relatives can also broaden our understanding of the complex systems that underlie social communicative behavior and offer insight into how these systems go awry in ASD. An interactive model of genetic, neurobiological, environmental, and protective factors may explain why significant deficits are present in affected children while only mild challenges are measurable in relatives. In depth examinations of the familiality of component traits provide a more complete picture of ASD’s etiology.
Examinations of BAP profiles in families provides an opportunity to gain insight into how phenotype profiles may be inherited within families and informs understanding of varying underlying genetic mechanisms in particular families. For instance, particular BAP profiles may be more suggestive of chromosomal variations impacting specific genomic regions. Specifying particular family types using behavioral measures may allow for the identification of differing genetic mechanisms. Examination of carefully defined phenotypes is crucial in providing insight into behavioral manifestations of genetic events and broadening understanding of the etiology of complex disorders such as ASD.
Consideration of BAP traits in family members also has important clinical implications in terms of treatment planning. An understanding and awareness of parent/familial factors is crucial to the development of any intervention plan with a family seeking treatment for their child. Clinicians often individualize interventions for different children with the same diagnosis based on certain family characteristics and needs. Such family factors can include addressing specific treatment goals that parents have for their child, parent/child motivation for change, varying personality styles, skill level in implementing the intervention, and home and school environments. In ASD, awareness that BAP traits and certain cognitive features are present in some family members should be part of these overall family considerations.
For example, it is conceivable that a parent with decreased social motivation may perceive his or her child’s limited social motivation differently from a parent in a different family who considers an extensive social network essential. From the first parent’s perspective, desired treatment goals may deemphasize social engagement relative to other presenting problems while a parent in the latter family may consider goals around social interaction more important than interventions focused on other behaviors. Conversely, it is also possible that parents with decreased social motivation may consider the focus on social engagement in the treatment of their child to be paramount depending specific experiences surrounding their own level of social engagement. Therefore, it may not be the presence of BAP traits per se, but parents’ experience and perception of that trait in themselves and their child that may influence treatment planning. Thus, considerations of the BAP in clinical settings may be helpful in recommending and implementing the best and most appropriate treatments for a child.
The BAP has been used to help elucidate the genetic mechanisms in ASD and provide a clearer picture of the clinical phenotype of ASD. Although further work is certainly needed before the BAP can be fully incorporated into treatment planning, there have been significant advances in our understanding of and ability to assess the BAP. Clearly, these advances in our understanding of the BAP have set the stage for future clinical and scientific pursuits.
- E. Fombonne, “Epidemiological surveys of autism and other pervasive developmental disorders: an update,” Journal of Autism and Developmental Disorders, vol. 33, no. 4, pp. 365–382, 2003.
- P. Howlin, S. Goode, J. Hutton, and M. Rutter, “Adult outcome for children with autism,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 45, no. 2, pp. 212–229, 2004.
- R. Luyster, J. Richler, S. Risi et al., “Early regression in social communication in autism spectrum disorders: a CPEA study,” Developmental Neuropsychology, vol. 27, no. 3, pp. 311–336, 2005.
- S. Steffenburg, C. Gillberg, L. Hellgren et al., “A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 30, no. 3, pp. 405–416, 1989.
- A. Bailey, A. Le Couteur, I. Gottesman et al., “Autism as a strongly genetic disorder: evidence from a British twin study,” Psychological Medicine, vol. 25, no. 1, pp. 63–77, 1995.
- E. R. Ritvo, B. J. Freeman, and A. Mason-Brothers, “Concordance for the syndrome of autism in 40 pairs of afflicted twins,” American Journal of Psychiatry, vol. 142, no. 1, pp. 74–77, 1985.
- B. S. Abrahams and D. H. Geschwind, “Advances in autism genetics: on the threshold of a new neurobiology,” Nature Reviews Genetics, vol. 9, no. 5, pp. 341–355, 2008.
- S. Wolff, S. Narayan, and B. Moyes, “Personality characteristics of parents of autistic children: a controlled study,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 29, no. 2, pp. 143–153, 1988.
- S. Wolff and J. Chick, “Schizoid personality in childhood: a controlled follow-up study,” Psychological Medicine, vol. 10, no. 1, pp. 85–100, 1980.
- R. Landa, J. Piven, M. M. Wzorek, J. O. Gayle, G. A. Chase, and S. E. Folstein, “Social language use in parents of autistic individuals,” Psychological Medicine, vol. 22, no. 1, pp. 245–254, 1992.
- P. Szatmari, M. B. Jones, L. Tuff, G. Bartolucci, S. Fisman, and W. Mahoney, “Lack of cognitive impairment in first-degree relatives of children with pervasive developmental disorders,” Journal of the American Academy of Child and Adolescent Psychiatry, vol. 32, no. 6, pp. 1264–1273, 1993.
- P. Bolton, H. Macdonald, A. Pickles et al., “A case-control family history study of autism,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 35, no. 5, pp. 877–900, 1994.
- J. Piven, M. Wzorek, R. Landa et al., “Personality characteristics of the parents of autistic individuals,” Psychological Medicine, vol. 24, no. 3, pp. 783–795, 1994.
- E. Fombonne, P. Bolton, J. Prior, H. Jordan, and M. Rutter, “A family study of autism: cognitive patterns and levels in parents and siblings,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 38, no. 6, pp. 667–683, 1997.
- J. Piven, P. Palmer, R. Landa, S. Santangelo, D. Jacobi, and D. Childress, “Personality and language characteristics in parents from multiple- incidence autism families,” American Journal of Medical Genetics, vol. 74, no. 4, pp. 398–411, 1997.
- J. Piven, P. Palmer, D. Jacobi, D. Childress, and S. Arndt, “Broader autism phenotype: evidence from a family history study of multiple-incidence autism families,” American Journal of Psychiatry, vol. 154, no. 2, pp. 185–190, 1997.
- S. E. Folstein, S. L. Santangelo, S. E. Gilman et al., “Predictors of cognitive test patterns in autism families,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 40, no. 7, pp. 1117–1128, 1999.
- M. Murphy, P. F. Bolton, A. Pickles, E. Fombonne, J. Piven, and M. Rutter, “Personality traits of the relatives of autistic probands,” Psychological Medicine, vol. 30, no. 6, pp. 1411–1424, 2000.
- A. Pickles, E. Starr, P. Bolton et al., “Variable expression of the autism broader phenotype: findings from extended pedigrees,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 41, no. 4, pp. 491–502, 2000.
- J. Briskman, F. Happé, and U. Frith, “Exploring the cognitive phenotype of autism: weak ‘central coherence’ in parents and siblings of children with autism: II. Real-life skills and preferences,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 42, no. 3, pp. 309–316, 2001.
- D. V. M. Bishop, M. Maybery, A. Maley, D. Wong, W. Hill, and J. Hallmayer, “Using self-report to identify the broad phenotype in parents of children with autistic spectrum disorders: a study using the Autism-Spectrum Quotient,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 45, no. 8, pp. 1431–1436, 2004.
- D. V. M. Bishop, M. Maybery, D. Wong, A. Maley, and J. Hallmayer, “Characteristics of the broader phenotype in autism: a study of siblings using the children's communication checklist-2,” American Journal of Medical Genetics, vol. 141, no. 2, pp. 117–122, 2006.
- V. Di Michele, M. Mazza, R. Cerbo, R. Roncone, and M. Casacchia, “Deficits in pragmatic conversation as manifestation of genetic liability in autism,” Clinical Neuropsychiatry: Journal of Treatment Evaluation, vol. 4, no. 4, pp. 144–151, 2007.
- L. Surian, S. Baron-Cohen, and H. Van Der Lely, “Are children with autism deaf to gricean maxims?” Cognitive Neuropsychiatry, vol. 1, no. 1, pp. 55–71, 1996.
- M. Losh and J. Piven, “Social-cognition and the broad autism phenotype: identifying genetically meaningful phenotypes,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 48, no. 1, pp. 105–112, 2007.
- T. F. Ruser, D. Arin, M. Dowd et al., “Communicative competence in parents of children with autism and parents of children with specific language impairment,” Journal of Autism and Developmental Disorders, vol. 37, no. 7, pp. 1323–1336, 2007.
- A. J. O. Whitehouse, J. G. Barry, and D. J. M. Bishop, “The broader language phenotype of autism: a comparison with specific language impairment,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 48, no. 8, pp. 822–830, 2007.
- A. M. Scheeren and J. E. A. Stauder, “Broader autism phenotype in parents of autistic children: reality or myth?” Journal of Autism and Developmental Disorders, vol. 38, no. 2, pp. 276–287, 2008.
- M. Losh, R. Adolphs, M. D. Poe et al., “Neuropsychological profile of autism and the broad autism phenotype,” Archives of General Psychiatry, vol. 66, no. 5, pp. 518–526, 2009.
- A. J. Schwichtenberg, G. S. Young, M. Sigman, T. Hutman, and S. Ozonoff, “Can family affectedness inform infant sibling outcomes of autism spectrum disorders?” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 51, no. 9, pp. 1021–1030, 2010.
- S. Wheelwright, B. Auyeung, C. Allison, and S. Baron-Cohen, “Defining the broader, medium and narrow autism phenotype among parents using the Autism Spectrum Quotient (AQ),” Molecular Autism, vol. 1, no. 1, article 10, 2010.
- S. Baron-Cohen, S. Wheelwright, R. Skinner, J. Martin, and E. Clubley, “The autism-spectrum quotient (AQ): evidence from Asperger Syndrome/high-functioning autism, males and females, scientists and mathematicians,” Journal of Autism and Developmental Disorders, vol. 31, no. 1, pp. 5–17, 2001.
- R. S. E. Hurley, M. Losh, M. Parlier, J. S. Reznick, and J. Piven, “The broad autism phenotype questionnaire,” Journal of Autism and Developmental Disorders, vol. 37, no. 9, pp. 1679–1690, 2007.
- D. V. M. Bishop, The Children's Communication Checklist, Psychological Corporation, London, UK, 2nd edition, 2003.
- C. F. Norbury, M. Nash, G. Baird, and D. V. M. Bishop, “Using a parental checklist to identify diagnostic groups in children with communication impairment: a validation of the Children's Communication Checklist—2,” International Journal of Language and Communication Disorders, vol. 39, no. 3, pp. 345–364, 2004.
- J. N. Constantino, T. Przybeck, D. Friesen, and R. D. Todd, “Reciprocal social behavior in children with and without pervasive developmental disorders,” Journal of Developmental and Behavioral Pediatrics, vol. 21, no. 1, pp. 2–11, 2000.
- J. N. Constantino and R. D. Todd, “Genetic structure of reciprocal social behavior,” American Journal of Psychiatry, vol. 157, no. 12, pp. 2043–2045, 2000.
- J. N. Constantino, C. P. Gruber, S. Davis, S. Hayes, N. Passanante, and T. Przybeck, “The factor structure of autistic traits,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 45, no. 4, pp. 719–726, 2004.
- J. N. Constantino, C. Lajonchere, M. Lutz et al., “Autistic social impairment in the siblings of children with pervasive developmental disorders,” American Journal of Psychiatry, vol. 163, no. 2, pp. 294–296, 2006.
- A. Ho, R. D. Todd, and J. N. Constantino, “Brief report: autistic traits in twins vs. non-twins-A preliminary study,” Journal of Autism and Developmental Disorders, vol. 35, no. 1, pp. 129–133, 2005.
- J. A. Duvall, A. Lu, R. M. Cantor, R. D. Todd, J. N. Constantino, and D. H. Geschwind, “A quantitative trait locus analysis of social responsiveness in multiplex autism families,” American Journal of Psychiatry, vol. 164, no. 4, pp. 656–662, 2007.
- G. Dawson, A. Estes, J. Munson, G. Schellenberg, R. Bernier, and R. Abbott, “Quantitative assessment of autism symptom-related traits in probands and parents: broader phenotype autism symptom scale,” Journal of Autism and Developmental Disorders, vol. 37, no. 3, pp. 523–536, 2007.
- Y. J. Sung, G. Dawson, J. Munson, A. Estes, G. D. Schellenberg, and E. M. Wijsman, “Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment,” American Journal of Human Genetics, vol. 76, no. 1, pp. 68–81, 2005.
- L. Kanner, “Autistic disturbances of affective contact,” Nervous Child, vol. 2, pp. 217–250, 1943.
- G. J. August, M. A. Stewart, and L. Tsai, “The incidence of cognitive disabilities in the siblings of autistic children,” British Journal of Psychiatry, vol. 138, no. 5, pp. 416–422, 1981.
- J. Minton, M. Campbell, and W. H. Green, “Cognitive assessment of siblings of autistic children,” Journal of the American Academy of Child Psychiatry, vol. 21, no. 3, pp. 256–261, 1982.
- T. D. Baird and G. J. August, “Familial heterogeneity in infantile autism,” Journal of Autism and Developmental Disorders, vol. 15, no. 3, pp. 315–321, 1985.
- B. J. Freeman, E. R. Ritvo, A. Mason-Brothers et al., “Psychometric assessment of first-degree relatives of 62 autistic probands in Utah,” American Journal of Psychiatry, vol. 146, no. 3, pp. 361–364, 1989.
- S. Baron-Cohen and J. Hammer, “Parents of children with asperger syndrome: what is the cognitive phenotype?” Journal of Cognitive Neuroscience, vol. 9, no. 4, pp. 548–554, 1997.
- C. Hughes, M. H. Plumet, and M. Leboyer, “Towards a cognitive phenotype for autism: increased prevalence of executive dysfunction and superior spatial span amongst siblings of children with autism,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 40, no. 5, pp. 705–718, 1999.
- L. M. Elder, G. Dawson, K. Toth, D. Fein, and J. Munson, “Head circumference as an early predictor of autism symptoms in younger siblings of children with autism spectrum disorder,” Journal of Autism and Developmental Disorders, vol. 38, no. 6, pp. 1104–1111, 2008.
- I. Gamliel, N. Yirmiya, and M. Sigman, “The development of young siblings of children with autism from 4 to 54 months,” Journal of Autism and Developmental Disorders, vol. 37, no. 1, pp. 171–183, 2007.
- L. Christensen, T. Hutman, A. Rozga et al., “Play and developmental outcomes in infant siblings of children with autism,” Journal of Autism and Developmental Disorders, vol. 40, no. 8, pp. 946–957, 2010.
- L. Zwaigenbaum, S. Bryson, C. Lord et al., “Clinical assessment and management of toddlers with suspected autism spectrum disorder: insights from studies of high-risk infants,” Pediatrics, vol. 123, no. 5, pp. 1383–1391, 2009.
- P. Szatmari, J. E. MacLean, M. B. Jones et al., “The familial aggregation of the lesser variant in biological and nonbiological relatives of PDD probands: a family history study,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 41, no. 5, pp. 579–586, 2000.
- T. Pilowsky, N. Yirmiya, R. S. Shalev, and V. Gross-Tsur, “Language abilities of siblings to children with autism,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 44, no. 6, pp. 914–925, 2003.
- D. V. Bishop, “Developmental cognitive genetics: how psychology can inform genetics and vice versa,” Quarterly Journal of Experimental Psychology, vol. 59, no. 7, pp. 1153–1168, 2006.
- K. Toth, G. Dawson, A. N. Meltzoff, J. Greenson, and D. Fein, “Early social, imitation, play, and language abilities of young non-autistic siblings of children with autism,” Journal of Autism and Developmental Disorders, vol. 37, no. 1, pp. 145–157, 2007.
- L. Zwaigenbaum, S. Bryson, T. Rogers, W. Roberts, J. Brian, and P. Szatmari, “Behavioral manifestations of autism in the first year of life,” International Journal of Developmental Neuroscience, vol. 23, no. 2-3, pp. 143–152, 2005.
- W. L. Stone, C. R. McMahon, P. J. Yoder, and T. A. Walden, “Early social-communicative and cognitive development of younger siblings of children with autism spectrum disorders,” Archives of Pediatrics and Adolescent Medicine, vol. 161, no. 4, pp. 384–390, 2007.
- J. Brian, S. E. Bryson, N. Garon et al., “Clinical assessment of autism in high-risk 18-month-olds,” Autism, vol. 12, no. 5, pp. 433–456, 2008.
- T. Hutman, A. Rozga, A. D. Delaurentis, J. M. Barnwell, C. A. Sugar, and M. Sigman, “Response to distress in infants at risk for autism: a prospective longitudinal study,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 51, no. 9, pp. 1010–1020, 2010.
- I. Gamliel, N. Yirmiya, D. H. Jaffe, O. Manor, and M. Sigman, “Developmental trajectories in siblings of children with autism: cognition and language from 4 months to 7 years,” Journal of Autism and Developmental Disorders, vol. 39, no. 8, pp. 1131–1144, 2009.
- A. N. Bhat, J. C. Galloway, and R. J. Landa, “Social and non-social visual attention patterns and associative learning in infants at risk for autism,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 51, no. 9, pp. 989–997, 2010.
- L. V. Ibanez, D. S. Messinger, L. Newell, B. Lambert, and M. Sheskin, “Visual disengagement in the infant siblings of children with an autism spectrum disorder (ASD),” Autism, vol. 12, no. 5, pp. 473–485, 2008.
- S. J. Rogers, “What are infant siblings teaching us about Autism in infancy?” Autism Research, vol. 2, no. 3, pp. 125–137, 2009.
- J. Piven, J. Gayle, G. A. Chase et al., “A family history study of neuropsychiatric disorders in the adult siblings of autistic individuals,” Journal of the American Academy of Child and Adolescent Psychiatry, vol. 29, no. 2, pp. 177–183, 1990.
- J. Piven and P. Palmer, “Psychiatric disorder and the broad autism phenotype: evidence from a family study of multiple-incidence autism families,” American Journal of Psychiatry, vol. 156, no. 4, pp. 557–563, 1999.
- S. L. Smalley, J. McCracken, and P. Tanguay, “Autism, affective disorders, and social phobia,” American Journal of Medical Genetics—Neuropsychiatric Genetics, vol. 60, no. 1, pp. 19–26, 1995.
- P. F. Bolton, A. Pickles, M. Murphy, and M. Rutter, “Autism, affective and other psychiatric disorders: patterns of familial aggregation,” Psychological Medicine, vol. 28, no. 2, pp. 385–395, 1998.
- N. Micali, S. Chakrabarti, and E. Fombonne, “The broad autism phenotype: findings from an epidemiological survey,” Autism, vol. 8, no. 1, pp. 21–37, 2004.
- B. Ingersoll and D. Z. Hambrick, “The relationship between the broader autism phenotype, child severity, and stress and depression in parents of children with autism spectrum disorders,” Research in Autism Spectrum Disorders, vol. 5, no. 1, pp. 337–344, 2011.
- E. Fombonne, P. Bolton, J. Prior, H. Jordan, and M. Rutter, “A family study of autism: cognitive patterns and levels in parents and siblings,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 38, no. 6, pp. 667–683, 1997.
- S. Gokcen, E. Bora, S. Erermis, H. Kesikci, and C. Aydin, “Theory of mind and verbal working memory deficits in parents of autistic children,” Psychiatry Research, vol. 166, no. 1, pp. 46–53, 2009.
- J. E. Lainhart, S. Ozonoff, H. Coon et al., “Autism, regression, and the broader autism phenotype,” American Journal of Medical Genetics, vol. 113, no. 3, pp. 231–237, 2002.
- A. J. Lincoln, E. Courchesne, B. A. Kilman, R. Elmasian, and M. Allen, “A study of intellectual abilities in high-functioning people with autism,” Journal of Autism and Developmental Disorders, vol. 18, no. 4, pp. 505–524, 1988.
- F. Happé, “Autism: cognitive deficit or cognitive style?” Trends in Cognitive Sciences, vol. 3, no. 6, pp. 216–222, 1999.
- J. Piven and P. Palmer, “Cognitive deficits in parents from multiple-incidence autism families,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 38, no. 8, pp. 1011–1021, 1997.
- G. L. Schmidt, L. K. Kimel, E. Winterrowd, B. F. Pennington, S. L. Hepburn, and D. C. Rojas, “Impairments in phonological processing and nonverbal intellectual function in parents of children with autism,” Journal of Clinical and Experimental Neuropsychology, vol. 30, no. 5, pp. 557–567, 2008.
- A. Shah and U. Frith, “An islet of ability in autistic children: a research note,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 24, no. 4, pp. 613–620, 1983.
- A. Shah and U. Fritht, “Why do autistic individuals show superior performance on the block design task?” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 34, no. 8, pp. 1351–1364, 1993.
- L. Mottron, J. A. Burack, J. E. A. Stauder, and P. Robaey, “Perceptual processing among high-functioning persons with autism,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 40, no. 2, pp. 203–211, 1999.
- K. Plaisted, J. Swettenham, and L. Rees, “Children with autism show local precedence in a divided attention task and global precedence in a selective attention task,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 40, no. 5, pp. 733–742, 1999.
- S. Ozonoff, D. L. Strayer, W. M. McMahon, and F. Filloux, “Executive function abilities in autism and Tourette Syndrome: an information processing approach,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 35, no. 6, pp. 1015–1032, 1994.
- F. Happé, J. Briskman, and U. Frith, “Exploring the cognitive phenotype of autism: weak “central coherence” in parents and siblings of children with autism: I. Experimental tests,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 42, no. 3, pp. 299–307, 2001.
- A. Nydén, B. Hagberg, V. Goussé, and M. Rastam, “A cognitive endophenotype of autism in families with multiple incidence,” Research in Autism Spectrum Disorders, vol. 5, no. 1, pp. 191–200, 2011.
- R. E. McEvoy, S. J. Rogers, and B. F. Pennington, “Executive function and social communication deficits in young autistic children,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 34, no. 4, pp. 563–578, 1993.
- S. Ozonoff, B. F. Pennington, and S. J. Rogers, “Executive function deficits in high-functioning autistic individuals: relationship to theory of mind,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 32, no. 7, pp. 1081–1105, 1991.
- C. Hughes, M. Leboyer, and M. Bouvard, “Executive function in parents of children with autism,” Psychological Medicine, vol. 27, no. 1, pp. 209–220, 1997.
- S. Ozonoff, S. J. Rogers, J. M. Farnham, and B. F. Pennington, “Can standard measures identify subclinical markers of autism?” Journal of Autism and Developmental Disorders, vol. 23, no. 3, pp. 429–441, 1993.
- K. Holmboe, M. Elsabbagh, A. Volein et al., “Frontal cortex functioning in the infant broader autism phenotype,” Infant Behavior and Development, vol. 33, no. 4, pp. 482–491, 2010.
- D. Wong, M. Maybery, D. V. M. Bishop, A. Maley, and J. Hallmayer, “Profiles of executive function in parents and siblings of individuals with autism spectrum disorders,” Genes, Brain and Behavior, vol. 5, no. 8, pp. 561–576, 2006.
- D. L. Koczat, S. J. Rogers, B. F. Pennington, and R. G. Ross, “Eye movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probands,” Journal of Autism and Developmental Disorders, vol. 32, no. 6, pp. 513–518, 2002.
- R. Delorme, V. Goussé, I. Roy et al., “Shared executive dysfunctions in unaffected relatives of patients with autism and obsessive-compulsive disorder,” European Psychiatry, vol. 22, no. 1, pp. 32–38, 2007.
- L. Dorris, C. A. E. Espie, F. Knott, and J. Salt, “Mind-reading difficulties in the siblings of people with Asperger's syndrome: evidence for a genetic influence in the abnormal development of a specific cognitive domain,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 45, no. 2, pp. 412–418, 2004.
- P. Szatmari, S. Georgiades, E. Duku, L. Zwaigenbaum, J. Goldberg, and T. Bennett, “Alexithymia in parents of children with autism spectrum disorder,” Journal of Autism and Developmental Disorders, vol. 38, no. 10, pp. 1859–1865, 2008.
- M. Shaked, I. Gamliel, and N. Yirmiya, “Theory of mind abilities in young siblings of children with autism,” Autism, vol. 10, no. 2, pp. 173–187, 2006.
- D. V. M. Bishop, T. North, and C. Donlan, “Nonword repetition as a behavioural marker for inherited language impairment: evidence from a twin study,” Journal of Child Psychology and Psychiatry and Allied Disciplines, vol. 37, no. 4, pp. 391–403, 1996.
- D. V. M. Bishop, S. J. Bishop, P. Bright, C. James, T. Delaney, and P. Tallal, “Different origin of auditory and phonological processing problems in children with language impairment: evidence from a twin study,” Journal of Speech, Language, and Hearing Research, vol. 42, no. 1, pp. 155–168, 1999.
- M. M. Kjelgaard and H. Tager-Flusberg, “An investigation of language impairment in autism: implications for genetic subgroups,” Language and Cognitive Processes, vol. 16, no. 2-3, pp. 287–308, 2001.
- K. A. Lindgren, S. E. Folstein, J. B. Tomblin, and H. Tager-Flusberg, “Language and reading abilities of children with autism spectrum disorders and specific language impairment and their first-degree relatives,” Autism Research, vol. 2, no. 1, pp. 22–38, 2009.
- J. A. Roberts, M. L. Rice, and H. Tager-Flusberg, “Tense marking in children with autism,” Applied Psycholinguistics, vol. 25, no. 3, pp. 429–448, 2004.
- A. J. O. Whitehouse, J. G. Barry, and D. V. M. Bishop, “Further defining the language impairment of autism: is there a specific language impairment subtype?” Journal of Communication Disorders, vol. 41, no. 4, pp. 319–336, 2008.
- M. Losh, D. Esserman, and J. Piven, “Rapid automatized naming as an index of genetic liability to autism,” Journal of Neurodevelopmental Disorders, vol. 2, no. 2, pp. 109–116, 2010.
- D. V. M. Bishop, M. Maybery, D. Wong, A. Maley, W. Hill, and J. Hallmayer, “Are phonological processing deficits part of the broad autism phenotype?” American Journal of Medical Genetics—Neuropsychiatric Genetics, vol. 128, no. 1, pp. 54–60, 2004.
- A. Bailey, S. Palferman, L. Heavey, and A. Le Couteur, “Autism: the phenotype in relatives,” Journal of Autism and Developmental Disorders, vol. 28, no. 5, pp. 369–392, 1998.
- E. Courchesne, R. Carper, and N. Akshoomoff, “Evidence of brain overgrowth in the first year of life in autism,” Journal of the American Medical Association, vol. 290, no. 3, pp. 337–344, 2003.
- C. K. Deutsch and R. M. Joseph, “Brief report: cognitive correlates of enlarged head circumference in children with autism,” Journal of Autism and Developmental Disorders, vol. 33, no. 2, pp. 209–215, 2003.
- Y. A. Dementieva, D. D. Vance, S. L. Donnelly et al., “Accelerated head growth in early development of individuals with autism,” Pediatric Neurology, vol. 32, no. 2, pp. 102–108, 2005.
- J. E. Lainhart, E. D. Bigler, M. Bocian et al., “Head circumference and height in autism: a study by the collaborative program of excellence in autism,” American Journal of Medical Genetics A, vol. 140, no. 21, pp. 2257–2274, 2006.
- B. F. Sparks, S. D. Friedman, D. W. Shaw et al., “Brain structural abnormalities in young children with autism spectrum disorder,” Neurology, vol. 59, no. 2, pp. 184–192, 2002.
- J. Piven, S. Arndt, J. Bailey, S. Havercamp, N. C. Andreasen, and P. Palmer, “An MRI study of brain size in autism,” American Journal of Psychiatry, vol. 152, no. 8, pp. 1145–1149, 1995.
- R. Sacco, R. Militerni, A. Frolli et al., “Clinical, morphological, and biochemical correlates of head circumference in autism,” Biological Psychiatry, vol. 62, no. 9, pp. 1038–1047, 2007.
- D. J. Fidler, J. N. Bailey, and S. L. Smalley, “Macrocephaly in autism and other pervasive developmental disorders,” Developmental Medicine and Child Neurology, vol. 42, no. 11, pp. 737–740, 2000.
- J. H. Miles, L. L. Hadden, T. N. Takahashi, and R. E. Hillman, “Head circumference is an independent clinical finding associated with autism,” American Journal of Medical Genetics, vol. 95, no. 4, pp. 339–350, 2000.
- S. J. M. C. Palmen, H. E. Hulshoff Pol, C. Kemner et al., “Brain anatomy in non-affected parents of autistic probands: a MRI study,” Psychological Medicine, vol. 35, no. 10, pp. 1411–1420, 2005.
- J. N. Constantino, P. Majmudar, A. Bottini, et al., “Infant head growth in male siblings of children with and without autism spectrum disorders,” Journal of Neurodevelopmental Disorders, vol. 2, no. 1, pp. 39–46, 2010.
- S. Baron-Cohen, H. Ring, X. Chitnis et al., “fMRI of parents of children with Asperger Syndrome: a pilot study,” Brain and Cognition, vol. 61, no. 1, pp. 122–130, 2006.
- G. Dawson, S. J. Webb, E. Wijsman et al., “Neurocognitive and electrophysiological evidence of altered face processing in parents of children with autism: implications for a model of abnormal development of social brain circuitry in autism,” Development and Psychopathology, vol. 17, no. 3, pp. 679–697, 2005.
- K. M. Dalton, B. M. Nacewicz, A. L. Alexander, and R. J. Davidson, “Gaze-fixation, brain activation, and amygdala volume in unaffected siblings of individuals with autism,” Biological Psychiatry, vol. 61, no. 4, pp. 512–520, 2007.
- M. Elsabbagh, A. Volein, G. Csibra et al., “Neural correlates of eye gaze processing in the infant broader autism phenotype,” Biological Psychiatry, vol. 65, no. 1, pp. 31–38, 2009.
- W. R. Kates, C. P. Burnette, S. Eliez et al., “Neuroanatomic variation in monozygotic twin pairs discordant for the narrow phenotype for autism,” American Journal of Psychiatry, vol. 161, no. 3, pp. 539–546, 2004.
- D. C. Rojas, J. A. Smith, T. L. Benkers, S. L. Camou, M. L. Reite, and S. J. Rogers, “Hippocampus and amygdala volumes in parents of children with autistic disorder,” American Journal of Psychiatry, vol. 161, no. 11, pp. 2038–2044, 2004.
- E. Peterson, G. L. Schmidtc, J. R. Tregellasa, et al., “A voxel-based morphometry study of gray matter in parents of children with autism,” NeuroReport: For Rapid Communication of Neuroscience Research, vol. 17, no. 12, pp. 1289–1292, 2006.
- J. N. Constantino and R. D. Todd, “Intergenerational transmission of subthreshold autistic traits in the general population,” Biological Psychiatry, vol. 57, no. 6, pp. 655–660, 2005.
- S. Bölte and F. Poustka, “The recognition of facial affect in autistic and schizophrenic subjects and their first-degree relatives,” Psychological Medicine, vol. 33, no. 5, pp. 907–915, 2003.
- Y. V. Virkud, R. D. Todd, A. M. Abbacchi, Y. Zhang, and J. N. Constantino, “Familial aggregation of quantitative autistic traits in multiplex versus simplex autism,” American Journal of Medical Genetics B, vol. 150, no. 3, pp. 328–334, 2009.
- M. Losh, D. Childress, K. Lam, and J. Piven, “Defining key features of the broad autism phenotype: a comparison across parents of multiple- and single-incidence autism families,” American Journal of Medical Genetics B, vol. 147, no. 4, pp. 424–433, 2008.
- J. Sebat, B. Lakshmi, D. Malhotra et al., “Strong association of de novo copy number mutations with autism,” Science, vol. 316, no. 5823, pp. 445–449, 2007.
- C. R. Marshall, A. Noor, J. B. Vincent et al., “Structural variation of chromosomes in autism spectrum disorder,” American Journal of Human Genetics, vol. 82, no. 2, pp. 477–488, 2008.
- L. A. Weiss, Y. Shen, J. M. Korn et al., “Association between microdeletion and microduplication at 16p11.2 and autism,” The New England Journal of Medicine, vol. 358, no. 7, pp. 667–675, 2008.
- S. Bölte, S. Knecht, and F. Poustka, “A case-control study of personality style and psychopathology in parents of subjects with autism,” Journal of Autism and Developmental Disorders, vol. 37, no. 2, pp. 243–250, 2007.
- W. H. Berrettini, “Genetic bases for endophenotypes in psychiatric disorders,” Dialogues in Clinical Neuroscience, vol. 7, no. 2, pp. 95–101, 2005.
- T. D. Gould and I. I. Gottesman, “Psychiatric endophenotypes and the development of valid animal models,” Genes, Brain and Behavior, vol. 5, no. 2, pp. 113–119, 2006.
- I. I. Gottesman and T. D. Gould, “The endophenotype concept in psychiatry: etymology and strategic intentions,” American Journal of Psychiatry, vol. 160, no. 4, pp. 636–645, 2003.