Sertraline May Improve Language Developmental Trajectory in Young Children with Fragile X Syndrome: A Retrospective Chart Review

Table 3

Change in expressive and receptive language (raw) MSEL scores.

					Average score at age 20 months				Average score, age at 40 months
					ON sertraline		OFF sertraline		ON sertraline		OFF sertraline
Outcome	Variable	Coefficient	SE^1	P value	Estimate^2	SE	Estimate	SE	Estimate	SE	Estimate	SE
Expressive language	Intercept	4.594	1.9994	0.0265	9.72	1.89	9.09	1.20	22.36	1.49	13.59	0.91
	Group (sertraline)	−7.5049	3.7628	0.0525
	Age	0.2249	0.04961	<.0001
	Age×group	0.4067	0.0948	<.0001
Receptive language	Intercept	6.4653	1.837	0.001	15.32	1.81	11.47	1.13	25.14	1.45	16.48	0.89
	Group (sertraline)	−0.9751	3.4644	0.7797
	Age	0.2504	0.04488	<.0001
	Age×group	0.2408	0.08528	0.0071

¹SE : etandard error.
²Model-based estimate of mean expressive/receptive language score.