IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients

Figure 4

Seizures outcome during IGF1 treatment. The figure shows the outcome of seizures during one year starting with D0. The dotted lines represent the start (D0) and the end (D180) of the treatment. Each patient is color-coded: S1: blue, S2: red, S3: green, S4: purple, S5: cyan, and S6: orange. The black vertical lines represent seizures episodes. The color-coded horizontal straight lines represent the therapy for seizures (valproic acid), while the dashed color-coded lines represent the IGF1 treatment that lasted from D0 to D180. Patients S1, S2, and S3 had seizures before the start of IGF1 treatment, and they were simultaneously treated with valproic acid and IGF1. S6 did not develop seizures. S4 had one single episode of seizures around D90, and the treatment with valproic acid started only after D180, when the seizures become frequent. S5 showed frequent seizures around P90 and the treatment with valproic acid started immediately.