IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients

Figure 5

Clinical assessment of IGF1 treatment on breathing. The graph reports the clinical evaluation of respiratory activity at each visit compared with the previous observation. D0 (first day of treatment, before IGF administration), D90 (90 days after the first IGF1 administration), D180 (180 days after the first IGF administration, last day of IGF1 treatment), D270 (270 days after the first IGF administration), and D365 (365 days after the first IGF administration). The dotted lines represent the start (D0) and the end (D180) of the treatment. Each patient is color-coded: S1: blue, S2: red, S3: green, S4: purple, S5: cyan, and S6: orange. The starting score at D0 was 0, and it was decreased or increased if the respiration improved or worsened, respectively. All the patients, with the exception of S1, showed an improved respiratory activity during IGF1 treatment. The improvement across all the patients is significant between D0, and D90 (Wilcoxon test). After the IGF1 administration was interrupted, respiration worsened for all the patients. The worsening occurred in the majority of cases immediately after the interruption, for two patients (S1 and S6) after D270.