Clinical Study

IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients

Figure 6

Effects of IGF1 treatment on bone density. (a): row values for bone density for each patient at D0 (empty histogram) and D365 (filled histogram). D0 (first day of treatment, before IGF administration), D90 (90 days after the first IGF1 administration), D180 (180 days after the first IGF administration, last day of IGF1 treatment), D270 (270 days after the first IGF administration), D365 (365 days after the first IGF administration). The dotted lines represent the start (D0) and the end (D180) of the treatment. Each patient is color-coded: S1: blue, S2: red, S3: green, S4: purple, and S6: orange. (b) Percentage of change between bone density at D365 versus bone density at D0. The majority of patients showed a ratio of 1, while for S3 and S6 the ratio was bigger than one showing an increase in bone mass after the treatment.
679801.fig.006a
(a)
679801.fig.006b
(b)