IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients

Figure 8

Effects of IGF1 treatment on International Severity Scale (ISS). The graph reports the clinical evaluation of the parameters of the International Severity Scale (ISS). D0 (first day of treatment, before IGF administration), D90 (90 days after the first IGF1 administration), D180 (180 days after the first IGF administration, last day of IGF1 treatment), D270 (270 days after first IGF administration), and D365 (365 days after first IGF administration). The dotted lines represent the start (D0) and the end (D180) of the treatment. Each patient is color-coded: S1: blue, S2: red, S3: green, S4: purple, S5: cyan, and S6: orange. At each visit the patients were evaluated and the score for the ISS annotated. An increase in the score shows a worsening of the conditions, while a decrease in the ISS score represents an improvement. During IGF treatment (D0–D180), half of the patients showed an improvement in the ISS score. Between D180 and D270, the ISS score increased for all the patients with the exception of S5 and S6. At D365, S6 and S4 had an improved ISS, score, while S3 had the same score as that at D0. S5, S2, and S1 had a higher ISS score at D365 than at D0. The improvement in ISS score is not significant considering the entire cohort of patients.