IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients

Figure 9

IGF1 treatment is safe and tolerated by patients. Representation of the possible side effects of IGF1 in all of the treated patients: hypoglycemia (H-G), tonsillar hypertrophy (H-T-T), mammary hyperplasia (H-M), and seizures (S) at different times after IGF1 administration (D90, D180, D270, and D365) and correlation with IGF1 administration in all the treated patients. In the graph is reported the score for all the possible side effects in each subject and the correlation between the symptom and IGF1 administration (colorbar values from 1 to 5). The graph shows that only one patient—between D90 and D180—presented moderate mammary hyperplasia (score 3). This event is highly correlated to the IGF1 treatment (correlation score 5, values on the right) but disappeared spontaneously and without the administration of additional therapy. Two additional patients showed seizures during the treatment (score 1) but these are not associated with IGF1 treatment (correlation score 1).