The Relationship of HLA Class I and II Alleles and Haplotypes with Autism: A Case Control Study
Table 1
HLA-A*, -B*, and -C* allele frequencies in autistic children and controls.
HLA
Autism
Controls
Statistical analysis
OR (95% CI)
A*01
12 (17.6)
15 (7.50)
2.68 (1.08–6.42)
0.03
A*02
30 (42.8)
54 (27.00)
3.02 (1.56–5.83)
0.001
A*11
2 (2.9)
7 (3.50)
0.83 (0.11–4.54)
1.00
A*23
2 (2.9)
12 (6.00)
0.47 (0.07–2.3)
0.51
A*26
6 (8.8)
10 (5.00)
1.8 (0.56–5.71)
0.34
A*29
2 (2.9)
4 (2.00)
1.48 (0.18–9.71)
1.00
A*31
8 (11.8)
12 (6.00)
2.1 (0.73–5.81)
0.19
A*32
2 (2.9)
10 (5.00)
0.51 (0.08–2.9)
0.71
A*33
4 (5.9)
8 (4.00)
1.5 (0.36–5.7)
0.75
A*68
4 (5.9)
20 (10.00)
0.56 (0.15–1.83)
0.43
B*07
10 (14.7)
10 (5.00)
3.27 (1.19–9.03)
0.01
B*08
4 (5.90)
12 (6.00)
0.97 (0.25–3.4)
1.00
B*14
4 (5.90)
3 (1.50)
4.1 (0.75–28.31)
0.12
B*15
4 (5.90)
12 (6.00)
0.97 (0.25–3.43)
1.00
B*18
4 (5.90)
7 (3.50)
1.73 (0.4–6.8)
0.60
B*35
2 (2.90)
16 (8.00)
0.34 (0.05–1.6)
0.24
B*40
2 (2.90)
3 (1.50)
1.94 (0.22–15.0)
0.81
B*41
4 (5.90)
9 (4.50)
1.32 (0.33–4.9)
0.85
B*44
2 (2.90)
4 (2.00)
1.48 (0.18–9.7)
1.00
B*50
8 (11.80)
28 (14.00)
0.82 (0.32–2.1)
0.79
B*51
16 (23.50)
42 (21.00)
1.15 (0.57–2.3)
0.78
B*52
4 (5.90)
6 (3.00)
2.01 (0.46–8.4)
0.47
B*57
2 (2.90)
3 (1.50)
2.01 (0.46–8.1)
0.47
B*58
2 (2.90)
7 (3.50)
0.85 (0.11–4.5)
1.00
C*01
2 (2.90)
4 (2.00)
1.48 (0.18–9.7)
1.00
C*04
4 (5.90)
25 (12.50)
0.43 (0.12–1.3)
0.19
C*05
2 (2.90)
2 (1.00)
3.0 (0.29–30.5)
0.57
C*06
12 (17.60)
31 (15.50)
1.16 (0.52–2.56)
0.82
C*07
12 (17.60)
43 (21.50)
0.78 (0.36–1.66)
0.61
C*08
4 (5.90)
4 (2.00)
3.1 (0.62–15.0)
0.22
C*12
6 (8.80)
16 (8.00)
1.11 (0.37–3.2)
1.00
C*15
16 (23.50)
32 (16.00)
1.6 (0.77–3.3)
0.22
C*16
4 (5.90)
10 (5.00)
1.1 (0.32–4.3)
1.00
C*17
6 (8.80)
10 (5.00)
1.84 (0.57–5.7)
0.33
AF: allele frequency; OR: odds ratio; 95% CI: confidence interval; NS: not significant. : each individual was represented by two codominant allelic data. The bold font in table refers to significant association of alleles and haplotype with autism.
