The Relationship of HLA Class I and II Alleles and Haplotypes with Autism: A Case Control Study
Table 2
The HLA-DRB1* and DQB1* alleles frequencies in autistic children and controls.
HLADR
Autism
Controls
Statistical analysis
OR (95% CI)
DRB1*0102
4 (5.89)
5 (2.50)
2.4 (0.38–10.8)
0.34
DRB1*0301
10 (14.7)
26 (13.00)
1.15 (0.48–2.6)
0.80
DRB1*0403
4 (5.89)
13 (6.50)
0.89 (0.23–3.1)
1.00
DRB1*0701
10 (14.7)
33 (16.50)
0.87 (0.37–1.9)
0.80
DRB1*1101
6 (8.82)
7 (3.50)
2.66 (0.7–9.2)
0.50
DRB1*1104
8 (11.76)
3 (1.50)
8.7 (2.0–43.1)
0.001
DRB1*1301
6 (8.82)
15 (7.50)
1.19 (0.3–3.4)
0.90
DRB1*1302
4 (5.89)
11 (5.50)
1.07 (0.27–3.8)
1.00
DRB1*1501
4 (5.89)
11 (5.50)
1.07 (0.27–3.8)
1.00
DRB1*1502
4 (2.94)
6 (3.00)
0.98 (1.13–5.5)
1.00
DRB1*1601
4 (5.89)
8 (4.00)
1.5 (0.36–5.7)
0.70
DQB1
DQB1*0201
10 (14.7)
51 (25.50)
0.5 (0.2–1.11)
0.09
DQB1*0202
8 (11.76)
72 (36.00)
0.24 (0.09–0.58)
0.001
DQB1*0301
14 (20.59)
37 (18.50)
1.14 (0.5–2.3)
0.80
DQB1*0302
4 (5.88)
59 (29.50)
0.14 (0.04–0.45)
0.001
DQB1*0303
2 (2.94)
8 (4.50)
0.72 (0.10–3.8)
0.97
DQB1*0402
2 (2.94)
8 (4.50)
0.72 (0.10–3.8)
0.97
DQB1*0501
4 (5.88)
40 (20.00)
0.25 (0.07–0.77)
0.012
DQB1*0502
4 (5.88)
22 (11.00)
0.5 (0.14–1.6)
0.30
DQB1*0503
2 (2.94)
4 (2.00)
1.4 (0.18–9.7)
1.00
DQB1*0601
2 (2.94)
13 (6.50)
0.4 (0.06–2.11)
0.40
DQB1*0602
4 (5.88)
25 (12.50)
0.4 (0.12–1.3)
0.19
DQB1*0603
8 (11.76)
35 (17.50)
0.6 (0.25–1.5)
0.35
DQB1*0604
2 (2.94)
16 (8.00)
0.34 (0.05–1.6)
0.24
AF: allele frequency; OR: odds ratio; 95% CI: confidence interval; NS: not significant. : each individual was represented by two codominant allelic data. The bold font in table refers to significant association of alleles and haplotype with autism.
