Review Article
A Need for Consistency in Behavioral Phenotyping for ASD: Analysis of the Valproic Acid Model
| Reference | Behaviors analyzed | Coding methods | Duration (min) | Outcome |
| Markram et al. [8] | Time spent in open and closed arms, total distance, and total velocity | Not specified | 5 | VPA spent less time in open arms than control. Distance and velocity were the same | Kataoka et al. [5] | Time spent and entries into open and closed arms | Manually scored from video (blind) | 5 | VPA males and females spent less time in open arms and more time in closed arms compared to control | Chen et al. [11] | Percent time spent in each arm and total distance | EthoVision | 5 | VPA males spent less time in open arms compared to control | Kim et al. [12] | Relative stay time ratio (open/closed) | EthoVision | 5 | VPA spent more time in open arms | Campolongo et al. [16] | Time spent in arms, distance traveled in arms, rearing, grooming, and head dips | ANY-maze for locomotion, manual for behavioral (blind) | 5 | VPA and saline spent same amount of time in open and closed arms |
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