Research Article
Does Cytomegalovirus Develop Resistance following Antiviral Prophylaxis and Treatment in Renal Transplant Patients in Kuwait?
Table 2
UL54 mutations in clinical CMV isolates resistant to GCV [
9].
| Region | UL54 mutation | Amino acid change |
| IV | N408D F412C D413E | Asparagine to aspartic acid Phenylalanine to cycteine Aspartic acid to glutamic acid |
| δ-region C | L501F | Leucine to phenylalanine | L501I | Leucine to isoleucine | T503I | Threonine to isoleucine | K503R | Lysine to arginine | K513E | Lysine to glutamic acid | P522A | Proline to alanine | T700A | Threonine to alanine |
| II | T700A | Threonine to alanine | M715V | Valine to methionine | I722V | Isoleucine to valine |
| VI | V781I | Valine to isoleucine |
| III | L802M | Leucine to methionine | A809V | Alanine to valine | G841A | Glycine to alanine |
| Other | S676G | Serine to glycine | G678S | Glycine to serine | Y751H | Tyrosine to histidine |
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