A Systemic Network Triggered by Human Cytomegalovirus Entry
Figure 5
Samples of in silico gene knockout in the network enhanced by HCMV entry. (a) Entire wild-type network enhanced by HCMV entry with highlighted genes with big size to be knocked out. Blue: potential bottleneck nodes; green: potential hubs. (b) Knocking out hubs and bottlenecks alter network structure. Knocking out hubs decreases local subnetwork linkages while most of their linked neighbors would not affected. Highlighted in green circle are the consequences of knockout EGFR and IL4 with only 6 genes and 1 gene, respectively, affected by knockout, but most of genes linked to EGFR and IL4 still link to the network after knockout. Conversely, knocking out bottleneck nodes breaks down the entire network into at least two separated networks as highlighted in blue circles.
