Review Article

Phylogeny-Directed Search for Murine Leukemia Virus-Like Retroviruses in Vertebrate Genomes and in Patients Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer

Figure 4

gag sequences of 300 high scoring mouse gammaretroviral sequences were aligned together with reference sequences. MLV sequences with ascribed tropism, from GenBank, were also added. The tree was rooted with a divergent rabbit gammaretrovirus-like sequence from scaffold 34, position 34101473 (oryCun1 assembly). Sequences in red (“HMRV”) are from the paper of Lo et al. [56]. They were from ME/CFS patients (“CFS”) or blood donors (“BD”). Two blood donor sequences from the Lo et al. study came out at the base of group G2, in other trees (not shown) at the base of group G3. The other emerged in group G3. The branch labels are either ERV host genus, chromosomal position, provisional genus (“C”: gamma), and ReTe score, or a reference Pol name. Genomic ERV sequences taken from the prototype of RetroBank were named as oryCun: rabbit, cavPor: guinea pig, felCat: cat, panTro: chimpanzee, or rheMac: rhesus macaque. Mouse sequences are just shown with their chromosomal location.
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