Review Article

Murine Leukemia Viruses: Objects and Organisms

Figure 6

MLV Env protein. MLV Env protein consists of a complex between and . The cartoon shows that gp70 has two domains, RBD at its N-terminus and “C-term” at its C-terminus, separated by a variable, proline-rich linker. P15E contains, from N- to C-terminus, the fusion peptide (FP), an N-terminal helical domain (helix A), a short C-terminal helical domain (helix B), and a C-terminal domain (light pink) which spans the viral membrane (yellow). Gp70 is exclusively external to the virus and is connected to p15E by a disulfide linkage between one of the two cysteines in a CXXC motif within its C-terminal domain and the last cysteine in a CX6CC motif in p15E.
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