Antiviral and Virucidal Activities of N𝜶-Cocoyl-L-Arginine Ethyl Ester

Figure 1

Inactivation of HSV-1. The virus was incubated in the solution indicated below for 5 min at 30°C. Number of infectious virus was determined by a plaque assay on Vero cells after the incubation and was normalized to that incubated in PBS. Arginine (0.5 M at pH 4.0 in 10 mM citrate), ButArg (0.5 M in pH 4.0 in 10 mM citrate), CAE (0.2% in 5 mM citrate and 0.15 M NaCl at pH 4.8), Amisafe (0.2% in 5 mM citrate and 0.15 M NaCl at pH 4.8), Aminosoap (0.2% in 5 mM citrate at pH 7.0), Amilite (0.2% in 5 mM citrate at pH 8.0), BKC (0.1% in 5 mM citrate at pH 7.0), SDS (0.2% in 5 mM citrate at pH 7.0), LS (0.2% in 5 mM citrate at pH 7.0), CHX (0.5% at pH 6.0), EtOH (70% in 5 mM citrate at pH 7.0), PI (0.23% in 5 mM citrate at pH 3.5), NaOCl (100 ppm in 5 mM phosphate at pH 7.0), and PBS (pH 7.4).