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Advances in Virology
Volume 2011 (2011), Article ID 813651, 16 pages
http://dx.doi.org/10.1155/2011/813651
Review Article

MoMuLV-ts-1: A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk

1Department of Physiology and Pharmacology, Block Health Science Building, College of Medicine, University of Toledo, Health Science Campus, Toledo, OH 43614, USA
2Department of Medicine, Ruppert Building, College of Medicine, University of Toledo, Health Science Campus, Toledo, OH 43614, USA

Received 31 January 2011; Revised 16 May 2011; Accepted 6 June 2011

Academic Editor: Paul Jolicoeur

Copyright © 2011 J. Chakraborty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Our laboratory has developed a murine model of lymphoma via breast milk transmission of MoMuLV-ts-1 (Moloney murine leukemia virus-temperature sensitive mutant-1). Uninfected offspring suckled from infected surrogate mothers become infected and develop lymphoma. Multiple gene integration sites of ts-1 into the infected mouse genome including tacc3, aurka, ndel1, tpx2, p53, and rhamm were identified, and mRNA expressions were quantitated. These genes produce centrosomal proteins, which may be involved in abnormal chromosomal segregation leading to aneuploidy or multiploidy, thus causing lymphoma. Since there is no report to date on this retroviral model leading to centrosomal abnormality, and causing lymphoma development, this is a valuable and unique model to study the centrosomal involvement in lymphomagenesis.