Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples

Figure 3

Derivation of the 22Rv1 cell line from prostate cancer xenografts in nude mice. Starting in 1992, the CWR22 prostate cancer was passaged repeatedly in nude mice until 1999, when the cell line was isolated. Samples of the tumor prior to 1996 were negative for XMRV, but contained small amounts of mouse DNA harboring both PreXMRV-1 and -2. Later samples were also positive for XMRV. Modified from Paprotka et al. [19].