Naturally Occurring Polymorphisms of the Mouse Gammaretrovirus Receptors CAT-1 and XPR1 Alter Virus Tropism and Pathogenicity
Figure 2
Structure of the FrMLV E-MLV Env gene. (a) Stick figure representation identifies the surface (SU) and transmembrane (TM) domains, the receptor binding domain (RBD) containing three variable regions (VRA, VRB, and VRC), and the proline-rich domain (PRD). Green triangles mark the N-linked glycosylation sites in SU. Vertical lines identify residues with roles in entry; the three residues in red form the binding pocket. The C-terminal segments designated C2 and loop10 have also been implicated in entry [42, 43]. (b) Surface representation of the FrMLV RBD (PDB ID 1AOL) [36], showing the location of the binding pocket (red), additional residues involved in entry (blue), and two N-linked glycosylation sites (green).
