Table 1: List of all known Tat protein interactions and the nature of the functional activity compiled from PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) and HIV-1, Human Protein Interaction Database (http://www.ncbi.nlm.nih.gov/RefSeq/HIVInteractions/).

Human protein Type of activity with Tat 2′-5′-Oligoadenylate synthetase 2 isoform 1 Interacts 2′-5′-Oligoadenylate synthetase 3 Interacts 2′,3′-Cyclic nucleotide 3′ phosphodiesterase Activates 2′,5′-Oligoadenylate synthetase 1 isoform 2 Interacts 8-Oxoguanine DNA glycosylase isoform 1a Upregulates Actin, gamma 1 propeptide Induces rearrangement of Activated RNA polymerase II transcription cofactor 4 Binds Adaptor-related protein complex 2, alpha 1, 2 beta-1, mu-1, and sigma-1 Interacts Adenosine A2a receptor Inhibited by Adenylate cyclase 2–9 Inhibits AFF4 Involved in transcription Albumin precursor Induces release Alpha 1 actin precursor Induces rearrangement Alpha 1 type-I collagen preproprotein Inhibits Alpha 2 actin Induces rearrangement Alpha 2 type-I collagen Inhibits Alpha isoform of regulatory subunit A, B55, protein phosphatase 2 Modulated by Alpha-2-macroglobulin precursor Inhibits AMP-activated protein kinase gamma 2 subunit isoform a Activates AMP-activated protein kinase, noncatalytic gamma-1 subunit isoform 1 Activates Amyloid beta A4 protein precursor, isoform a Inhibits Annexin A2 isoform 2 Downregulates Apolipoprotein E precursor Inhibited by ATP-binding cassette subfamily B, C member 1 Upregulates ATP-dependent DNA helicase II Interacts ATP-dependent DNA helicase II, 70 kDa subunit Interacts Autoantigen La Interacts B-cell CLL/lymphoma 11B isoform 1 Binds B-cell lymphoma 6 protein Upregulates B-cell lymphoma protein 2 alpha isoform Interacts Baculoviral IAP repeat-containing protein 3 Upregulates BCL2-antagonist of cell death protein Induces phosphorylation BCL2-associated athanogene isoform 1L Upregulates BCL2-associated X protein isoform beta Interacts BCL2-like 1 isoform 1 Upregulates BCL2-like 11 isoform 6 Interacts Beta actin Induces rearrangement Beta isoform of regulatory subunit A, B55 and B56, protein phosphatase 2 isoform a Modulated by Beta tubulin 1, class VI Binds Beta-2-microglobulin precursor Downregulates Bone-morphogenetic protein 1, 2 isoform 1, precursor Upregulates Bone-morphogenetic protein receptor type-II precursor Downregulates Brain adenylate cyclase 1 Inhibits Breast cancer antiestrogen resistance 1 Induces phosphorylation BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170 kDa Interacts with c-Src tyrosine kinase Activates Calcium/calmodulin-dependent protein kinase I Downregulates Calcium/calmodulin-dependent protein kinase IIA, IIB isoform 1 Inhibits cAMP-responsive element-binding protein 1 isoform A Activates cAMP-responsive element modulator isoform v Activates cAMP-dependent protein kinase catalytic subunit beta isoform 1 Activates cAMP-dependent protein kinase, regulatory subunit alpha 1 and beta 2 Activates cAMP-specific phosphodiesterase 4D Activates Cardiac muscle alpha actin 1 proprotein Induces rearrangement Caspase 3 preproprotein Activates Caspase 8 isoform A precursor Upregulates CC chemokine receptor 3 Binds CCAAT/enhancer binding protein Binds CCAAT/enhancer binding protein beta Binds CD180 antigen Downregulates CD28 antigen Interacts CD3D antigen, delta polypeptide isoform A precursor Interacts CD3E antigen, epsilon polypeptide (TiT3 complex) Interacts CD3G gamma precursor Interacts CD4 antigen precursor Upregulates CD40 antigen isoform 1 precursor Upregulates Cell division cycle 2 protein isoform 1 Interacts Cell division cycle 20 and 25C protein Downregulates Cell division cycle 37 protein Regulated by Cell division cycle 6 protein Interacts Chaperonin containing TCP1, subunit 4 (delta) Interacts Chemokine (C motif) ligand 1, 3, 7 Upregulates Chemokine (C-C motif) receptor 1 Modulates Chemokine (C-C motif) receptor 2 isoform B Binds Chemokine (C-C motif) receptor 4 Upregulated by Chemokine (C-C motif) receptor 5 Upregulates Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) isoform beta Interacts Chemokine (C-X-C motif) receptor 3 Inhibits Chemokine (C-X-C motif) receptor 4 isoform b Binds Chemokine (C-X3-C motif) ligand 1 Inhibited by Chemokine C-C motif ligand 4 isoform 1 precursor Upregulates Chromobox homolog 5 (HP1 alpha homolog, Drosophila) Inactivates Class II transactivator Inhibits Claudin 1 Downregulates Claudin 5 Downregulates Cleavage and polyadenylation specific factor 3, 73 kDa Upregulates Cofactor of BRCA1 Associates with Cofilin 1 (nonmuscle) Downregulates Cofilin 2 (muscle) Downregulates Collagen, type-III, alpha 1 preproprotein Upregulates Colony-stimulating factor 2 precursor Upregulates Complement component 1 inhibitor precursor Upregulates Complement component 1, q subcomponent-binding protein precursor Binds Core histone macro-H2A2.2 Binds CREB-binding protein isoform a Binds CREB3: cAMP-responsive element binding protein 3 (luman) Inhibited by CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 isoform FCP1a Binds CXCL16 Interacts Cyclin A, A1, E1 Interacts Cyclin B1 Upregulates Cyclin C isoform a Interacts Cyclin D1 Downregulates Cyclin D3 Interacts Cyclin H Binds Cyclin T1 Binds Cyclin T2 isoform a Binds Cyclin-dependent kinase 2 isoform 1 Enhances Cyclin-dependent kinase 4 Interacts Cyclin-dependent kinase 5 Downregulates Cyclin-dependent kinase 7 Binds Cyclin-dependent kinase 8 Interacts Cyclin-dependent kinase 9 Binds Cyclin-dependent kinase inhibitor 1A Activates Cyclin-dependent kinase inhibitor 1B Interacts Cytochrome c Induces release of Cytoplasmic nuclear factor of activated T cells 3 isoform 1 Activates Cytoplasmic nuclear factor of activated T cells 4 Activates Delta isoform of regulatory subunit B56, protein phosphatase 2A isoform 1 Modulated by Dicer1 Interacts Dipeptidyl peptidase IV Inhibits Diubiquitin Ubiquitinated by DNA-dependent protein kinase Modulates HIV gene expression DNA-directed RNA polymerase II polypeptides Interacts DNA polymerase epsilon catalytic subunit Interacts DNA-damage-inducible transcript 3 Enhanced by DNA-directed RNA polymerase III 39 kDa polypeptide F Activates Dopamine transporter Inhibits Downregulator of transcription 1 Inhibits E1A-binding protein p300 Complexes with E2F transcription factor 1 Inhibited by E2F transcription factor 4 Recruits Early growth response 1, 2, 3 Binds Egr-1 in astrocytes Tat-mediated toxicity in astrocytes Elongation factor RNA polymerase II Interacts Elongin B isoform a Interacts Endonuclease G precursor Activates Endothelial differentiation-related factor 1 isoform alpha Downregulates Endothelin 1 Upregulates Enolase 1 Inhibits EP300 Binds Epidermal growth factor (beta urogastrone) Interacts Epsilon isoform of regulatory subunit B56, protein phosphatase 2A Modulated by Eukaryotic translation elongation factor 1 alpha 1, 2 Interacts Eukaryotic translation initiation factor 2-alpha kinase 2 Interacts Excision repair cross-complementing rodent repair deficiency, complementation group 2 protein Binds Excision repair cross-complementing rodent repair deficiency, complementation group 3 Binds Fas ligand Interacts Fc fragment of IgG, low affinity IIIa, receptor for (CD16) Inhibits Fibroblast growth factor 1 (acidic) isoform 1 precursor Upregulates Fibronectin 1 isoform 3 preproprotein Competes with Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Binds Furin preproprotein Cleaved by Galectin 3 Upregulates Gamma isoform of regulatory subunit B55, protein phosphatase 2 isoform a Regulated by Gastrointestinal glutathione peroxidase 2 Modulates GATA-binding protein 2 Synergizes with GCN5 general control of amino-acid synthesis 5-like 2 Binds Gelsolin isoform a precursor Downregulates General transcription factor iib, e, f, and h Interacts General transcription factor IIIC, polypeptide 1, alpha 220 kDa Activates GLI-Kruppel family member GLI2 Synergizes with Glial fibrillary acidic protein Upregulates Glucocerebrosidase precursor Interacts Glucose-6-phosphate dehydrogenase isoform a Activates Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A, 3B Activates Glutamate receptor, metabotropic 1 Activates Glutathione peroxidase 1 isoform 1, 4, 5, 6, 7 Downregulates Glutathione synthetase Modulates Glycogen synthase kinase 3 beta Activates Glycophorin A precursor Downregulates Granulin precursor Binds Grb2 Binds through SH3 domains Growth factor receptor-bound protein 2 isoform 1 Recruits Growth hormone 1 isoform 1 Inhibited by H2A histone family members Binds H2B histone family members Binds H3 histone family members Binds H4 histone family members Binds Heat shock 70 kDa proteins Regulated by Heparan sulfate proteoglycan 2 Interacts Heparanase Interacts Hexamethylene bis-acetamide inducible 1, 2 Inhibited by Histone 1, h2ad Binds Histone 2, H4 Binds Histone deacetylase 1 Inhibited by Histone h2a Binds Histone H2A Binds Histone H2B Binds Histone H4 Binds HIV TAT specific factor 1 Stimulated by HIV-1 Tat interactive protein 2, 30 kDa Stimulates HIV-1 Tat interactive protein, 60 kDa isoform 1 Binds HMT1 hnRNP methyltransferase-like 6 Methylated by Human immunodeficiency virus type-I enhancer binding protein 1 Enhanced by Inhibitor of DNA-binding 1 isoform a Upregulates Ini1/hSNF5 Interacts Inositol 1,4,5-triphosphate receptor, type 1, 2, 3 Interacts Insulin-like growth factor 1 (somatomedin C) Inhibited by Insulin-like growth factor-binding protein 4 precursor Binds Integrin alpha 3 isoform a precursor Activates Integrin alpha 5 precursor Binds Integrin alpha L precursor Inhibits Integrin beta 1 isoform 1A precursor Interacts Integrin beta 4 isoform 1 precursor Interacts Integrin beta chain, beta 3 precursor Interacts Integrin, beta 2 precursor Inhibits Integrin, beta 5 Interacts Intercellular adhesion molecule 1 precursor Interacts Interferon regulatory factor 1 Binds Interferon regulatory factor 7 isoform a Upregulates Interferon-stimulated gene 20 kDa Upregulates Interferon-induced protein 35 Upregulates Interferon-induced protein with tetratricopeptide repeats 3 Upregulates Interferon-induced, hepatitis C-associated microtubular aggregate protein Upregulates Interferon, alpha 1 Interacts Interferon, alpha-inducible protein (clone IFI-15 K) Upregulates Interferon, alpha-inducible protein 27 Upregulates Interferon, beta 1, fibroblast Interacts Interferon, gamma Inhibited by Interferon, gamma-inducible protein 16 Upregulates Interleukin 1 receptor antagonist isoform 2 Upregulates Interleukin 1 receptor, type I precursor Upregulates Interleukin 1, alpha proprotein Downregulates Interleukin 1, beta proprotein Downregulates Interleukin 10 precursor Inhibited by Interleukin 12A precursor Downregulates Interleukin 12B precursor Downregulates Interleukin 13 precursor Induces release of Interleukin 16 isoform 1 precursor Inhibited by Interleukin 19 isoform 1 precursor Upregulates Interleukin 2 precursor Downregulates Interleukin 2 receptor beta precursor Downregulates Interleukin 2 receptor, alpha chain precursor Upregulates Interleukin 20 precursor Upregulates Interleukin 3 precursor Upregulates Interleukin 4 isoform 1 precursor Interacts Interleukin 6 (interferon, beta 2) Activated by Interleukin 6 receptor isoform 1 precursor Upregulates Interleukin 7 precursor Inhibits Interleukin 7 receptor precursor Inhibits Interleukin 8 precursor Downregulates Jun oncogene Binds Karyopherin beta 1 Binds Kinase insert domain receptor (a type-III receptor tyrosine kinase) Interacts with Kinesin family member 2C Downregulates Kruppel-like factor 9 Enhanced by Lactate dehydrogenase A Downregulates Lactate dehydrogenase B Downregulates Lamin A/C isoform 1 precursor Binds Lamin B1 Binds Lamin B2 Binds Laminin alpha 5 Upregulates Laminin subunit beta 3 precursor Upregulates Laminin, alpha 1 precursor Upregulates Laminin, alpha 4 precursor Upregulates Laminin, beta 1 precursor Upregulates Laminin, beta 2 precursor Upregulates Laminin, beta 4 Upregulates Laminin, gamma 1 precursor Upregulates Laminin, gamma 2 isoform a precursor Upregulates Laminin, gamma 3 precursor Upregulates Low affinity immunoglobulin gamma Fc region receptor III-B precursor Inhibits Low-density lipoprotein-related protein 1 Binds LSD1/KDM1 Modulates transcription Lymphocyte-specific protein tyrosine kinase precursor Activates Lymphotoxin alpha precursor Upregulates MAD, mothers against decapentaplegic homolog 6 Downregulates Major histocompatibility complex, class I Downregulates Major histocompatibility complex, class II Downregulates Manganese superoxide dismutase isoform A precursor Downregulates Mannose receptor C type-1 precursor Downregulates Mannose receptor C type 2 Downregulates Matrix metalloproteinase Activates Menage a trois 1 (CAK assembly factor) Binds Metallothioneins Upregulates Methyltransferase-like protein 1 isoform a Downregulates Microtubule-associated deacetylase HDAC6 Tat acetylation and transactivation Mitogen-activated protein kinases Activates Mothers against decapentaplegic homolog 3 Inhibited by Mothers against decapentaplegic homolog 4 Inhibited by Mouse double minute 2 homolog isoform MDM2 Regulated by Myc protooncogene protein Upregulates MyoD family inhibitor domain containing isoform p40 Binds Myxovirus resistance protein 1 Upregulates Nasal embryonic LHRH factor Associates with Nerve growth factor, beta polypeptide precursor Inhibits Neutrophil cytosolic factor 1 Interacts Nitric oxide synthase 2A isoform 1 Inhibits Nitric oxide synthase 3 (endothelial cell) Upregulates NMDA receptor 1 isoforms Activates Notch 2 preproprotein Interacts Nrf2 transcription factor Fusion to Tat Nuclear factor I/C isoform 1 Synergizes with Nuclear factor kappa-B, subunit 1 Interacts Nuclear factor of activated T cells, cytosolic component 1 isoform A Activates Nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 2 isoform B Binds Nuclear factor of kappa light polypeptide gene enhancer in B cells Activates Nuclear receptor coactivator 1 isoform 1 Stimulates Nuclear receptor coactivator 2 Stimulates Nuclear receptor coactivator 3 isoform a Enhanced by Nuclear receptor subfamily 2, group F, member 1 Interacts Nuclease-sensitive element binding protein 1 Binds Nucleophosmin 1 isoform 1 Binds Nucleosome assembly protein 1 Interacts P-TEFb Binds p21-activated kinase 1 Interacts p300/CBP-associated factor Interacts p65 Binds Paired mesoderm homeobox 1 isoform pmx-1a Downregulates Pancreas-enriched phospholipase C Activates Paxillin Induces phosphorylation of Phorbolin 1 Upregulates Phosphatase and tensin homolog Downregulates Phosphodiesterases Activates Phosphoinositide-3-kinases Interacts with Phosphoinositide-specific phospholipase C beta 1 isoform a Activates Phospholipase C isoforms Activates Plasma glutathione peroxidase 3 precursor Downregulates Plasminogen activator inhibitor-1 Modulates Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kDa) Interacts Poly(ADP-ribose) polymerase family, member 1 Regulates Poly(A) polymerase alpha Regulates Poly(A) polymerase beta (testis specific) Regulates Poly(A) polymerase gamma Regulates Polymerase (DNA directed), beta Upregulates Polymerase (RNA) III (DNA directed) polypeptides Activates Polypyrimidine tract-binding protein 2 Interacts Polypyrimidine tract-binding protein 1 isoform a Interacts POU domain, class 2, transcription factor 1 Binds PRF1: perforin 1 (pore forming protein) Downregulates Prion protein preproprotein Upregulates PRKC, apoptosis, WT1, regulator Upregulates Programmed cell death 11 Modulated by Proliferating cell nuclear antigen Interacts Promyelocytic leukemia protein isoform 1 Regulated by Prostaglandin-endoperoxide synthase 2 precursor Upregulates Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 Interacts Proteasome (prosome, macropain) activator subunit 4 Interacts Proteasome 26S ATPase subunits Interacts Proteasome 26S non-ATPase subunits Interacts Proteasome activator subunits Interacts Proteasome alpha subunits Interacts Proteasome beta subunits Interacts Proteasome inhibitor subunit 1 isoform 1 Interacts Protein kinase C Activates Protein kinase D Regulated by Protein kinase, camp dependent Activates Protein kinase, DNA-activated, catalytic polypeptide Binds Protein phosphatase 1 Through Cdk9 phosphorylation Protein phosphatase 1 regulatory inhibitor subunit 8 isoform alpha Binds Protein phosphatase 1, catalytic subunits Binds Protein phosphatase 2, catalytic subunits Modulated by Protein phosphatase 3, catalytic subunits Activates Protein tyrosine phosphatase, nonreceptor type 23 Upregulates Protooncogene tyrosine-protein kinase SRC Activates PTK2 protein tyrosine kinase 2 isoform a Activates PTK2B protein tyrosine kinase 2 beta isoform a Induces phosphorylation Purine-rich element-binding protein A Binds RAD51 homolog protein isoform 1 Interacts RAN-binding protein 5 Binds Ras homolog gene family, member A Activates Ras-related C3 botulinum toxin substrate 1 isoform Rac1 Activates Ras-related C3 botulinum toxin substrate 2 Activates RD RNA-binding protein Associates RelB Through inhibition of tnfα Replication factor C2 (40 kDa) isoform 1 Interacts Replication factor C3 isoform 1 Interacts Replication factor C4 Interacts Replication factor C5 isoform 1 Interacts Replication factor C large subunit Interacts Replication protein A1, 70 kDa Interacts Reticuloendotheliosis viral oncogene homolog B Interacts Retinoblastoma 1 Inhibited by Retinoblastoma-like 2 (p130) Binds Rho GDP dissociation inhibitor (GDI) alpha Downregulates Ribosomal protein L3 isoform a Interacts RNA guanylyltransferase and 5′-phosphatase Binds RNA polymerase II, polypeptide H Activates S-phase kinase-associated protein 2 isoform 1 Enhanced by Secretoglobin, family 2A, member 2 Upregulates Selectin E precursor Upregulates Semaphorin 4D Upregulates SHC (Src homology 2 domain containing) transforming protein 1 isoform p52Shc Induces phosphorylation of Signal transducer and activator of transcription 1 isoform alpha Upregulates Signal transducer and activator of transcription 3 isoform 2 Activates Signal transducer and activator of transcription 6 Interacts Single-stranded DNA-binding protein 1 Upregulates Sirtuin 1 Regulated by SKI-interacting protein Associates SKIP Interacts through c-Myc and Menin Small GTPase protein E-Ras Activates Small inducible cytokine precursors Inhibits Small inducible cytokine subfamily E, member 1 Upregulates Small nuclear ribonucleoprotein polypeptide Stimulated by Solute carrier family 22, member 1 isoform a Regulated by Solute carrier family 5 (sodium/glucose cotransporter), member 1 Inhibits Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Downregulates Sp1 transcription factor Interacts SP110 nuclear body protein isoform a Upregulates Sp3 transcription factor isoform 1 Interacts Sp4 transcription factor Interacts Spermidine/spermine N1 acetyltransferase Upregulates Splicing factor, arginine/serine-rich 1 isoform 1 Inhibits Splicing factor, arginine/serine-rich 7 Inhibits Squamous cell carcinoma antigen recognized by T cells 3 Regulated by SRB7 suppressor of RNA polymerase B homolog Interacts Src homology 2 domain containing transforming protein C3 Induces phosphorylation Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) Binds Superoxide dismutase 1, soluble Downregulates Superoxide dismutase 3, extracellular precursor Downregulates Suppressor of Ty 4 homolog 1 Activated by Suppressor of Ty 5 homolog Stimulated by SWI/SNF-related, matrix-associated, and actin-dependent regulator of chromatin Binds Syndecan 1–4 precursors Binds T-box 21 Upregulates T-cell receptor zeta chain isoform 1 precursor Interacts TAF12 RNA polymerase II, TATA box-binding protein (TBP)-associated factor, 20 kDa Interacts TAF9 RNA polymerase II isoform a Interacts TAR DNA-binding protein Inhibited by TAR RNA-binding protein 1 Regulates TAR RNA-binding protein 2 isoform a Synergizes TAT-interactive protein, 72 kDa Binds TATA box-binding protein Interacts TATA box-binding protein-associated factor 2F Interacts TBP-1 interacting protein isoform 2 Inhibited by TBP-associated factors Interacts Telomerase reverse transcriptase isoform 1 Downregulates Testis-specific histone H2B Binds TFIIA alpha, p55 isoform 1 Stabilizes TH1-like protein Associates Thrombospondin 1 precursor Binds Thyroid hormone receptor, alpha isoform 2 Binds Tight junction protein 2 (zona occludens 2) isoform 1 Downregulates Tissue inhibitor of metalloproteinase 1 precursor Interacts Tissue inhibitor of metalloproteinase 2 precursor Interacts TNF receptor-associated factor 4 Inhibited by Transcription elongation factor A (SII), 3 Interacts Transcription elongation factor A1 isoform 1 Interacts Transcription elongation factor A protein 2 isoform a Interacts Transcription elongation regulator 1 isoform 1 Associates with Transcription factor 3 Regulated by Transcription factor 4 isoform b Inhibits Transcription factor 7-like 2 (T-cell specific, HMG-box) Regulated by Transcription factor AP-4 (activating enhancer binding protein 4) Regulated by Transcription factor CP2 Inhibited by Transforming growth factor, alpha Upregulates Transforming growth factor, beta 1 Inhibited by Transforming growth factor, beta 2 Upregulates Transporter 1, ATP-binding cassette, subfamily B Upregulates Transportin 1 Binds Tripartite motif-containing 22 Inhibited by TUBB4Q: tubulin, beta polypeptide 4, member Q Downregulates Tubulin alpha 6 Binds Tubulin, alpha 1 Binds Tubulin, alpha 1a Binds Tubulin, alpha 2 isoform 1 Binds Tubulin, alpha 4 Binds Tubulin, alpha 8 Binds Tubulin, alpha, ubiquitous Binds Tubulin, beta Downregulates Tubulin, beta 2 Binds Tubulin, beta 2B Downregulates Tubulin, beta 4 Binds Tubulin, beta 6 Binds Tubulin, beta 8 Binds Tubulin, beta, 2 Binds Tubulin, beta, 4 Binds Tumor necrosis factor (ligand) superfamily, member 10 Inhibits Tumor necrosis factor alpha Interacts Tumor necrosis factor receptors Upregulates Tumor protein p53 Binds Tumor protein p73 Binds Tyrosine hydroxylase isoform b Downregulates Ubiquitin B precursor Ubiquitinated by Ubiquitin C Ubiquitinated by Ubiquitin-activating enzyme E1 Ubiquitinated by Ubiquitin-conjugating enzyme E2D 1 Ubiquitinated by Upstream-binding protein 1 (LBP-1a) Inhibits Urokinase plasminogen activator preproprotein Upregulates V-akt murine thymoma viral oncogene homolog 2 Activates V-akt murine thymoma viral oncogene homolog 3 isoform 1 Activates V-fos FBJ murine osteosarcoma viral oncogene homolog Interacts V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1 Activates V-rel reticuloendotheliosis viral oncogene homolog Interacts Vascular cell adhesion molecule 1 isoform a precursor Upregulates Vascular endothelial growth factor A isoform b precursor Cooperates with Vitronectin precursor Competes with Wolf-Hirschhorn syndrome candidate 2 protein Downregulates YY1 transcription factor Inhibited by Zinc finger and BTB domain containing 7A Binds